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Journal of Histochemistry and Cytochemistry, Vol. 49, 929-930, July 2001, Copyright © 2001, The Histochemical Society, Inc.

BRIEF REPORT

Comparison of Apoptosis and Terminal Differentiation: The Mammalian Aging Process

C.E. Gagnaa,b, H.-R. Kuob, E. Floreaa, W. Shamia, R. Taorminaa, N. Vaswania, M. Guptaa, R. Vijha, and W.C. Lambertb
a School of Allied Health & Life Sciences, New York Institute of Technology, Old Westbury, New York
b Department of Pathology and Laboratory Medicine, University of Medicine & Dentistry of New Jersey-Medical School, Newark, New Jersey

Correspondence to: C.E. Gagna, School of Allied Health & Life Sciences, NY Institute of Technology, NYCOM 2, Rm. 362, Old Westbury, NY 11568. E-mail: dr.c.gagna@att.net

Apoptosis is the ordered chain of events that lead to cell destruction. Terminal differentiation (denucleation) is the process in which cells lose their nuclei but remain functional. Our group examined cell death in three tissues using two different fixatives and a postfixation procedure, involving young (5 months) and old (2 years) guinea pigs. The data reveal that B-DNA and Z-DNA content decreases, whereas single-stranded (ss-) DNA increases, in older tissues undergoing apoptosis (skin and cornea) and terminal differentiation (ocular lens). We speculate that some of the factors that contribute to the aging process might also be responsible for the enhanced amount of damaged DNA in older tissues undergoing cell death. (J Histochem 49:929–930, 2001)

Key Words: apoptosis, terminal differentiation, B-DNA, Z-DNA, denatured DNA


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