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Journal of Histochemistry and Cytochemistry, Vol. 49, 983-988, August 2001, Copyright © 2001, The Histochemical Society, Inc.

ARTICLE

Immunohistochemistry of Omega Class Glutathione S-Transferase in Human Tissues

Zhan-Li Yina, Jane E. Dahlstroma,b,c, David G. Le Couteura,c, and Philip G. Boardc
a Canberra Clinical School of the Sydney University, The Canberra Hospital
b Department of Anatomical Pathology, The Canberra Hospital
c Division of Molecular Medicine, John Curtin School of Medical Research, Canberra, Australia

Correspondence to: Philip G. Board, Molecular Genetics Group, John Curtin Schl. of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia. E-mail: Philip.Board@anu.edu.au

Omega class glutathione transferase (GSTO) has been recently described in a number of mammalian species. We used immunohistochemistry to determine the cellular and tissue distribution of GSTO1-1 in humans. Expression of GSTO1-1 was abundant in a wide range of normal tissues, particularly liver, macrophages, glial cells, and endocrine cells. We also found nuclear staining in several types of cells, including glial cells, myoepithelial cells of the breast, neuroendocrine cells of colon, fetal myocytes, hepatocytes, biliary epithelium, ductal epithelium of the pancreas, Hoffbauer cells of the placenta, and follicular and C-cells of the thyroid. These observations and the known activity of GSTO1-1 suggest biological functions that are not shared with other GSTs. (J Histochem Cytochem 49:983–987, 2001)

Key Words: glutathione transferase, omega, GSTO, immunohistochemistry


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