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Journal of Histochemistry and Cytochemistry, Vol. 50, 1417-1420, October 2002, Copyright © 2002, The Histochemical Society, Inc.

BRIEF REPORT

HPV DNA Detection by In Situ Hybridization with Catalyzed Signal Amplification on Thin-layer Cervical Smears

Brigitte Samamaa, Salomé Plas–Rosera, Christiane Schaeffera, Danielle Chateaua, Michel Fabrea, and Nelly Boehma
a Institut d'Histologie, Faculté de Médecine, Strasbourg, France

Correspondence to: Brigitte Samama, Institut d'Histologie, Faculté de Médecine, 4 rue Kirschleger, 67085 Strasbourg Cedex, France. E-mail: Brigitte.Samama@medecine.u-strasbg.fr

Thin layer-based technology in cervical cancer screening now allows both Papanicolaou staining and HPV testing on the same sample. Here, we show that in situ hybridization with catalyzed reporter deposition is a powerful HPV detection method when applied on thin-layer cervical smears, allowing distinction between two staining patterns suggestive of two different physical states of HPV DNA, where diffuse signals are suggestive of episomes and punctate signals are suggestive of viral DNA integration

(J Histochem Cytochem 50:1417–1420, 2002)

Key Words: cervical smears, human papilloma virus, in situ hybridization, thin-layer cytology, tyramide amplification


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