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Journal of Histochemistry and Cytochemistry, Vol. 50, 1555-1562, November 2002, Copyright © 2002, The Histochemical Society, Inc.

ARTICLE

Angioarchitecture of Primary Oral Malignant Melanomas

You-Jin Leea, Noriyuki Nagaia, Chong-Huat Siarb, Keisuke Nakanoa, Hitoshi Nagatsukaa, Hidetsugu Tsujigiwaa, Cheng-Hsiung Roana, and Mehmet Gunduza
a Department of Oral Pathology and Medicine, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
b Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia

Correspondence to: Noriyuki Nagai, Dept. of Oral Pathology & Medicine, Graduate School of Medicine & Dentistry, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. E-mail: nori@md.okayama-u.ac.jp

Angiogenesis is an essential process in the progression of malignant tumors. However, little is known of the angioarchitecture in primary oral malignant melanoma. We sought to determine this by the use of periodic acid–Schiff (PAS) stain, endothelial markers (CD34, CD105) and laminin, and by transmission electron microscopy in two cases. The results demonstrated that endothelium-lined vessels dominated the tumor microvasculature and these stained positively for PAS, laminin, and endothelial markers. Mosaic and tumor-lined vessels were infrequently encountered. Most PAS-positive patterned networks and loops ultrastructurally represented intratumor microhemorrhages that probably arose secondary to tumor vessel leakiness. Vascular channels of the vasculogenic mimicry type were rare. They stained for laminin but not for endothelial markers.

(J Histochem Cytochem 50:1555–1562, 2002)

Key Words: tumor microvasculature, oral malignant melanoma, mosaic vessels, co-opted vessels, vascular channels, intracellular channels, periodic acid–Schiff stain, immunohistochemistry, transmission electron, microscopy


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