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Journal of Histochemistry and Cytochemistry, Vol. 50, 1677-1684, December 2002, Copyright © 2002, The Histochemical Society, Inc.

ARTICLE

Strong Expression of Interleukin-1 Receptor Type I in the Rat Carotid Body

Xi Wanga, Bai-Ren Wanga, Xiao-Li Duana, Ping Zhanga, Yu-Qiang Dinga, Yi Jiaa, Xi-Ying Jiaoa, and Gong Jua
a Department of Neuroimmunomodulation, Institute of Neurosciences, Fourth Military Medical University, Xi'an, China

Correspondence to: Gong Ju, Inst. of Neurosciences, The Fourth Military Medical University, Xi'an, P.R. China. E-mail: jugong@fmmu.edu.cn

One of the unsolved key questions in neuroimmunomodulation is how peripheral immune signals are transmitted to the brain. It has been reported that the vagus might play a role in this regard. The underlying mechanism for this immune system-to-brain communication route is related to the binding of cytokines, such as interleukin (IL)-1ß originating from activated immune cells, to their receptors in glomus cells of the vagal paraganglia. The existence of IL-1 receptor type I (IL-1RI) in vagal paraganglia has been proved. On the basis of these studies, a hypothesis is raised that the carotid body, as the largest paraganglion, might play a similar role to that of its abdominal partner. In this study we examined the distribution of IL-1RI in the carotid body by immunohistochemistry (IHC) and Western blotting techniques. The IHC results showed that almost all glomus cells in the carotid body displayed strong IL-1RI immunoreactivity. The IL-1RI-immunoreactive products were localized in the cytoplasm, nucleus, and cell membrane of the glomus cells. The Western blotting results also confirmed the existence of IL-1RI in both membranous and cytoplasmic elements of the carotid body. These results imply that the carotid body not only serves as a chemoreceptor for modulation of cardiorespiratory performance, as traditionally recognized, but also acts as a cytokine chemorereceptor for sensing immune signals. (J Histochem Cytochem 50:1677–1684, 2002)

Key Words: carotid body, interleukin-1 receptor type I, immunocytochemistry, rat


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