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Journal of Histochemistry and Cytochemistry, Vol. 50, 275-282, February 2002, Copyright © 2002, The Histochemical Society, Inc.

ARTICLE

Immunohistochemical Localization of Angiotensin II Receptor and Local Renin–Angiotensin System in Human Colonic Mucosa

Koki Hirasawaa, Yoshihiko Satoa, Yoshisuke Hosodaa, Tastuo Yamamotoa, and Hiroyuki Hanaib
a First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
b Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan

Correspondence to: Koki Hirasawa, First Department of Medicine, Hamamatsu U. School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan. E-mail: k_shimo@bea.hi-ho.ne.jp

Angiotensin II (Ang II) regulates water and sodium transport in renal tubules and gastrointestinal tract. Two types of Ang II receptors have been cloned, but their distributions have not been determined in human colon. In addition, tissue renin–angiotensin systems (RAS) are believed to exist and to regulate local actions in human colon. We studied by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC) the presence and localization of Ang II receptors Type 1 (AT1), Type 2 (AT2), and RAS components [angiotensinogen, renin, and angiotensin-converting enzyme (ACE)] in normal human colon. AT1 receptors were localized in vessel walls, myofibroblasts, macrophages, and surface epithelium. AT2 receptors were found in mesenchymal cells and weakly in parts of surface epithelium. Renin and ACE were distributed in vessel walls, mesenchymal cells, and in parts of surface epithelium. Angiotensinogen was also detected by RT-PCR. These findings demonstrated that Ang II receptors and RAS components were present in human colon, suggesting the possibility of its local regulation. (J Histochem Cytochem 50:275–282, 2002)

Key Words: renin–angiotensin system, angiotensin II receptor, human colon


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