Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaarteenaho–Wiik, R.
Right arrow Articles by Pääkkö, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaarteenaho–Wiik, R.
Right arrow Articles by Pääkkö, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry, Vol. 50, 423-431, March 2002, Copyright © 2002, The Histochemical Society, Inc.

ARTICLE

Tenascin-C Is Highly Expressed in Respiratory Distress Syndrome and Bronchopulmonary Dysplasia

Riitta Kaarteenaho–Wiika, Vuokko L. Kinnulaa, Riitta Hervaa, Ylermi Soinia, Raimo Pöllänena, and Paavo Pääkköa
a Departments of Internal Medicine and Pathology, University of Oulu and Oulu University Hospital, Oulu, Finland

Correspondence to: Riitta Kaarteenaho–Wiik, Dept. of Internal Medicine, PO Box 5000 (Kajaanintie 50), FIN-90014 Oulun Yliopisto, Finland.

Tenascin-C is an extracellular matrix (ECM) glycoprotein expressed in human tissues during organogenesis and in fibrotic and neoplastic processes. We hypothesized that its expression would increase in human lung in neonatal disorders such as infant respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD). Tenascin-C expression was studied by immunohistochemistry (IHC) and mRNA in situ hybridization (ISH). The extent of tenascin-C immunoreactivity was scored as absent (0), low (+), moderate (++), strong (+++), or very strong (++++) separately in different types of pulmonary cells in controls (seven cases), RDS (19 cases), and BPD (12 cases). In controls, tenascin-C expression was low (+) underneath alveolar and bronchiolar epithelium, moderate (++) in intima of veins, and strong (+++) around chondrocytes. In RDS, tenascin-C expression was moderate (++) or strong (+++) underneath both bronchiolar and often detached alveolar epithelium underlying hyaline membranes in the walls of dilated alveoli. In particular, the patients with RDS who survived for 1 day or more had strong expression of tenascin-C within alveolar walls. In patients with BPD, tenascin-C was very strongly (++++) expressed in the remodeled fibrotic alveolar walls underneath regenerative epithelium. Increased expression of tenascin-C mRNA was seen below the alveolar and bronchiolar epithelia in RDS and BPD. The cells in these locations showed {alpha}-smooth muscle actin immunoreactivity, suggesting a myofibroblast phenotype. In conclusion, tenascin-C is highly expressed in the walls of alveoli and bronchioli in RDS and BPD, suggesting an association between the expression of this protein and the presence of these disorders. (J Histochem Cytochem 50:423–431, 2002)

Key Words: extracellular matrix, hyaline membrane disease


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. G. R. Thompson, J. D. Mih, T. B. Krasieva, B. J. Tromberg, and S. C. George
Epithelial-derived TGF-beta2 modulates basal and wound-healing subepithelial matrix homeostasis
Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1277 - L1285.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. C. Wesselkamper, L. M. Case, L. N. Henning, M. T. Borchers, J. W. Tichelaar, J. M. Mason, N. Dragin, M. Medvedovic, M. A. Sartor, C. R. Tomlinson, et al.
Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor {beta}
Am. J. Respir. Crit. Care Med., December 1, 2005; 172(11): 1399 - 1411.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. Matsuda, T. Hirota, M. Akahoshi, M. Shimizu, M. Tamari, A. Miyatake, A. Takahashi, K. Nakashima, N. Takahashi, K. Obara, et al.
Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma
Hum. Mol. Genet., October 1, 2005; 14(19): 2779 - 2786.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. G. Vicencio, C. G. Lee, S. J. Cho, O. Eickelberg, Y. Chuu, G. G. Haddad, and J. A. Elias
Conditional Overexpression of Bioactive Transforming Growth Factor-{beta}1 in Neonatal Mouse Lung: A New Model for Bronchopulmonary Dysplasia?
Am. J. Respir. Cell Mol. Biol., December 1, 2004; 31(6): 650 - 656.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
R. Kaarteenaho-Wiik and V. L. Kinnula
Distribution of Antioxidant Enzymes in Developing Human Lung, Respiratory Distress Syndrome, and Bronchopulmonary Dysplasia
J. Histochem. Cytochem., September 1, 2004; 52(9): 1231 - 1240.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2002