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Journal of Histochemistry and Cytochemistry, Vol. 50, 433-435, March 2002, Copyright © 2002, The Histochemical Society, Inc.

BRIEF REPORT

Human Lipocalin-1, a Physiological Scavenger of Lipophilic Compounds, Is Produced by Corticotrophs of the Pituitary Gland

Petra Wojnara, Stephan Dirnhoferb,c, Peter Ladurnerd, Peter Bergere, and Bernhard Redla
a Department of Molecular Biology, University Innsbruck, Innsbruck, Austria
b Institute of Pathology, University Innsbruck, Innsbruck, Austria
c Institute of Pathology, University Basel, Basel, Switzerland
d Department of Zoology, Faculty of Sciences, University Innsbruck, Innsbruck, Austria
e Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria

Correspondence to: Bernhard Redl, Institut für Molekularbiologie, Universität Innsbruck, Fritz Pregl Str. 3, A-6020 Innsbruck, Austria. E-mail: bernhard.redl@uibk.ac.at

Lipocalin-1 (Lcn-1), a member of the lipocalin superfamily that binds a broad array of different chemical classes of lipophilic ligands, is believed to act as a physiological scavenger of potentially harmful lipophilic molecules. Thus far, it was thought to be produced exclusively by a number of exocrine glands and tissues, including lachrymal and lingual glands, prostate, secretory glands of the tracheobronchial tract, and sweat glands. Using Northern blotting analysis, we were able to demonstrate Lcn-1 expression by the human pituitary gland. Moreover, double immunolabeling with antibodies against Lcn-1 and pituitary gland hormones and detection with fluorophore-conjugated secondary antibodies revealed that Lcn-1 is specifically produced by corticotrophs, clearly indicating that its distribution is not restricted to exocrine tissues. (J Histochem Cytochem 50:433–435, 2002)

Key Words: lipocalin, pituitary gland, immunohistochemistry, adenohypophysis, corticotrophs


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