Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kang, J. S.
Right arrow Articles by Park, M. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kang, J. S.
Right arrow Articles by Park, M. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry
Volume 51 (11): 1447-1458, 2003
Copyright ©The Histochemical Society, Inc.

Follicular Expression of c-Kit/SCF and Inhibin-{alpha} in Mouse Ovary During Development

Jae Seong Kang, Chang Joo Lee, Jong Min Lee, Joong Yeol Rha, Kang Won Song and Moon Hyang Park

Department of Obstetrics and Gynecology, Korea University Hospital (JSK,CJL,JYR); Department of Obstetrics and Gynecology, Gachon Medical School (JML); and Department of Pathology, College of Medicine, Hanyang University, (KWS,MHP), Seoul, Korea

Correspondence to: Moon Hyang Park, Dept. of Pathology, College of Medicine, Hanyang University, 17, Haengdang-dong, Seongdong-gu, Seoul, Republic of Korea. E-mail: parkmh{at}hanyang.ac.kr

The mechanism of development of the ovarian follicles has been largely unknown. We performed an immunohistochemical (IHC) study to determine the follicular expressions of c-kit, SCF, and inhibin-{alpha} at different developmental stages in mouse ovary. Ovaries were obtained from 14 and 16 days post coitum and 2, 7, and 21 days post partum (dpp) mice. IHC for c-kit, SCF, and inhibin-{alpha} was carried out. c-Kit and SCF were expressed on oogonia regardless of the developmental stage. Immunoreactive c-kit and SCF antigens were expressed on oocytes of primordial and primary follicles of neonate mouse ovaries. In 21 dpp mouse ovary, the expression of c-kit/SCF in oocytes gradually decreased as the follicles developed. c-Kit/SCF was expressed strongly in oocytes of preantral follicles and weakly in granulosa and thecal cells. Inhibin-{alpha} was mainly expressed on granulosa cells of preantral and early antral follicles of the 21 dpp mouse ovaries. These findings suggest that the IHC expression of c-kit/SCF proteins is specific in all developmental stages of ovarian follicles and is decreased after the follicle starts to grow. The expression of inhibin-{alpha} is negatively correlated with the expression of c-kit/SCF in the ovarian follicles in mice.

(J Histochem Cytochem 51:1447–1458, 2003)

Key Words: mouse ovary • follicle • c-Kit/SCF • inhibin-{alpha}


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol Hum ReprodHome page
K.J. Hutt, E.A. McLaughlin, and M.K. Holland
Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis
Mol. Hum. Reprod., February 1, 2006; 12(2): 61 - 69.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
M. K. Skinner
Regulation of primordial follicle assembly and development
Hum. Reprod. Update, September 1, 2005; 11(5): 461 - 471.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
P. R. Kezele, J. M. Ague, E. Nilsson, and M. K. Skinner
Alterations in the Ovarian Transcriptome During Primordial Follicle Assembly and Development
Biol Reprod, January 1, 2005; 72(1): 241 - 255.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2003