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Journal of Histochemistry and Cytochemistry
Volume 51 (12): 1575-1580, 2003
Copyright ©The Histochemical Society, Inc.

Decreased Expression of the Low-density Lipoprotein Receptor-related Protein-1 (LRP-1) in Rats with Prostate Cancer

Mónica B. Gilardoni, Danilo G. Ceschin, María M. Sahores, Mabel Oviedo, Ricardo C. Gehrau and Gustavo A. Chiabrando

Departamento de Bioquímica Clínica (MBG,DGC,MMS,RCG,GAC) and Laboratorio de Histopatología (MO), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

Correspondence to: Gustavo A. Chiabrando, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Haya de la Torre y Medina Allende Ciudad Universitaria, (5000) Córdoba, Argentina. E-mail: gustavo{at}bioclin.fcq.unc.edu.ar

The aim of this work was to evaluate by immunohistochemistry (IHC) the expression of both LRP-1 and urokinase-type plasminogen activator receptor (uPAR) at different developmental stages of rat prostate disease by using a prostate cancer model previously developed in our laboratory. We found that LRP-1 was weakly expressed in normal prostates and in rats with hyperplastic glands. The expression of this receptor increased and correlated with the degree of premalignant lesions (PIN I, II, and III). The IHC for uPAR in normal prostates and in premalignant lesions showed a score of immunostaining that correlated with the expression of LRP-1. On the other hand, in prostates with adenocarcinomas and undifferentiated carcinomas, LRP-1 was undetectable or weakly detected, whereas uPAR showed a significantly higher level of expression. Based on the IHC results in rat prostates with premalignant and malignant lesions and considering that LRP-1, by mediating the internalization of uPAR, is involved in the regulation of extracellular matrix remodeling and cell migration, we conclude that a decreased expression of LRP-1 could be involved with the increasing activation of plasminogen activators shown in cancers.

(J Histochem Cytochem 51:1575–1580, 2003)

Key Words: low-density lipoprotein • receptor-related protein • urokinase-type plasminogen • activator receptor • immunohistochemistry • prostate • cancer


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