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Journal of Histochemistry and Cytochemistry, Vol. 51, 159-166, February 2003, Copyright © 2003, The Histochemical Society, Inc.

ARTICLE

Enhanced Expression of Duffy Antigen in the Lungs During Suppurative Pneumonia

Janet S. Leea, Charles W. Freverta, David R. Thorningb, Stephan Segererb, Charles E. Alpersb, Jean-Pierre Cartronc, Yves Colinc, Venus A. Wonga, Thomas R. Martina, and Richard B. Goodmana
a Department of Medicine, Division of Pulmonary & Critical Care Medicine
b Department of Pathology
c VA Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, Washington, and INSERM U76, Institut National de La Transfusion Sanguine, Paris, France

Correspondence to: Richard B. Goodman, VA Puget Sound Health Care System, Pulmonary, 111B, 1660 South Columbian Way, Seattle, WA 98108. E-mail: goodmanr@u.washington.edu

Duffy antigen is a chemokine binding protein expressed on the surface of erythrocytes and postcapillary venular endothelial cells. It binds selective CXC and CC chemokines with high affinity. Although Duffy antigen is present in the normal pulmonary vascular bed, it is not known whether its expression is altered by innate inflammatory responses in the lungs. We studied Duffy antigen expression by immunohistochemistry in autopsy lung specimens from 16 cases of suppurative pneumonia, 11 cases of acute lung injury, and seven normal lungs. In lungs with suppurative pneumonia, Duffy antigen was expressed in higher numbers of pre- and postcapillary parenchymal vessels compared to normal specimens or specimens with acute lung injury (p<0.03 and p<0.02, respectively). Lungs with suppurative pneumonia also showed Duffy antigen expression on the alveolar septa, whereas this was a rare finding in normal specimens or in acute lung injury (p<0.02). Furthermore, Duffy antigen labeling of the alveolar septa localized to regions with airspace accumulation of neutrophil-rich exudates. In summary, Duffy antigen expression is increased in the vascular beds and alveolar septa of the lung parenchyma during suppurative pneumonia, suggesting that Duffy antigen may have a functional role in the lung parenchyma during inflammation. (J Histochem Cytochem 51:159–166, 2003)

Key Words: Duffy antigen, endothelial, chemokines, lungs, pneumonia


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