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Journal of Histochemistry and Cytochemistry, Vol. 51, 339-348, March 2003, Copyright © 2003, The Histochemical Society, Inc.

ARTICLE

Expression of the Giant Protein AHNAK (Desmoyokin) in Muscle and Lining Epithelial Cells

Benoit J. Gentila, Christian Delphina, Christelle Benauda, and Jacques Baudiera
a Laboratoire de Transduction du Signal INSERM EMI-0104, Grenoble, France

Correspondence to: Jacques Baudier, Departement Reponse et Dynamique Cellulaires, TS EMI 0104, DRDC, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France. E-mail: jbaudier@cea.fr

Here we report a detailed analysis of the expression and localization of the giant protein AHNAK in adult mouse tissues. We show that AHNAK is widely expressed in muscle cells, including cardiomyocytes, smooth muscle cells, skeletal muscle, myoepithelium, and myofibroblasts. AHNAK is also specifically expressed in epithelial cells of most lining epithelium, but is absent in epithelium with more specialized secretory or absorptive functions. In all adult tissues, the main localization of AHNAK is at the plasma membrane. A role for AHNAK in the specific organization and the structural support of the plasma membrane common to muscle and lining epithelium is discussed.

(J Histochem Cytochem 51:339–348, 2003)

Key Words: muscle, AHNAK, epithelium, tissue localization


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