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Journal of Histochemistry and Cytochemistry, Vol. 51, 429-433, April 2003, Copyright © 2003, The Histochemical Society, Inc.

REVIEW

Regulation of Growth Cone Extension by SNARE Proteins

Kazushi Kimuraa,b, Akira Mizoguchib, and Chizuka Idea
a Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
b Department of Anatomy, Faculty of Medicine, Mie University, Tsu, Japan

Correspondence to: Kazushi Kimura, Dept. of Anatomy and Neurobiology, Kyoto U. Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. E-mail: k-kimura@anat2.med.kyoto-u.ac.jp

Recent studies have suggested that the soluble N-ethylmaleimide-sensitive factor attached protein (SNAP) receptor (SNARE)-mediated membrane fusion system is involved in vesicle fusion with the surface plasma membrane, which leads to neurite elongation. There have been several reports analyzing the effects of neurite outgrowth by inhibition of SNAREs. We studied this mechanism by overexpressing GFP-fusion SNAREs including VAMP-2, SNAP-25A, and syntaxin1A in PC12 cells to investigate the role of SNAREs in neurite outgrowth. When overexpressed in PC12 cells, VAMP-2 promoted neurite elongation, whereas SNAP-25A stimulated neurite sprouting. On the other hand, overexpression of syntaxin1A neither promoted nor inhibited neurite outgrowth. Thus, VAMP-2 and SNAP-25A play different roles in neurite elongation and sprouting.

(J Histochem Cytochem 51:429–433, 2003)

Key Words: growth cone, SNARE, neurite outgrowth, vesicle


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