Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Savin, S. B.
Right arrow Articles by Jankovic, M. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Savin, S. B.
Right arrow Articles by Jankovic, M. M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry, Vol. 51, 479-483, April 2003, Copyright © 2003, The Histochemical Society, Inc.

ARTICLE

Expression of Galectin-1 and Galectin-3 in Human Fetal Thyroid Gland

Svetlana B. Savina, Dubravka S. Cvejica, and Miroslava M. Jankovica
a Institute for the Application of Nuclear Energy–INEP, University of Belgrade, Zemun–Belgrade, Yugoslavia

Correspondence to: Dubravka S. Cvejic, Inst. for the Application of Nuclear Energy–INEP, Banatska 31b, PO Box 46, 11080 Zemun–Belgrade, Yugoslavia. E-mail: dubravka@inep.co.yu

High levels of expression of galectin-1 and galectin-3, the ß-galactoside-binding proteins, have been recently described in malignant thyroid tumors but not in adenomas nor in normal thyroid tissue. However, there are no data about the expression of these galectins during fetal thyroid development. In this study we analyzed immunohistochemically the presence of galectin-1 and galectin-3 in human fetal thyroid glands (16–37 weeks of gestation). Weak to moderate cytoplasmic staining for galectin-1 was observed in follicular cells of all fetal thyroids. Galectin-3 could not be detected in thyroid follicular cells of any fetal thyroid investigated. Both galectins were detected in stromal tissue, but staining for galectin-1 was more intense. The absence of galectin-3 in thyroid cells during fetal development suggests that galectin-3 is expressed de novo during malignant transformation of thyroid epithelium, and that galectin-1 could be considered an oncofetal antigen. The results obtained indicated potential roles for galectin-1 and galectin-3 during the investigated period of human fetal thyroid gland development. Both galectins might participate in developmental processes regarding stromal fetal thyroid tissue organization, whereas galectin-1 might have a function in thyroid epithelium maturation.

(J Histochem Cytochem 51:479–483, 2003)

Key Words: galectin-1, galectin-3, human fetal thyroid, immunohistochemistry


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 GlycobiologyHome page
I. Camby, M. Le Mercier, F. Lefranc, and R. Kiss
Galectin-1: a small protein with major functions
Glycobiology, November 1, 2006; 16(11): 137R - 157R.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2003

 
Purchase HCS Short Course Manual on HCS site