Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Du, J.
Right arrow Articles by van Hasselt, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Du, J.
Right arrow Articles by van Hasselt, A. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry, Vol. 51, 533-539, April 2003, Copyright © 2003, The Histochemical Society, Inc.

ARTICLE

The Nuclear Localization of NF{kappa}B and p53 Is Positively Correlated with HPV16 E7 Level in Laryngeal Squamous Cell Carcinoma

Jing Dua,b, George G. Chena,b, Alexander C. Vlantisa, Hu Xua, Raymond K.Y. Tsanga, and Andrew C. van Hasselta
a Department of Surgery, Prince of Wales Hospital, the Chinese University of Hong Kong, Shatin, N.T. Hong Kong
b Sir Y.K. Pao Center for Cancer, Prince of Wales Hospital, the Chinese University of Hong Kong, Shatin, N.T. Hong Kong

Correspondence to: George G. Chen, Department of Surgery, Prince of Wales Hospital, U. of Hong Kong, Shatin, N.T. Hong Kong. E-mail: gchen@cuhk.edu.hk

The interaction between the HPV (human papilloma virus) 16 E7 and other cell growth factors, such as p53 and NF{kappa}B in laryngeal cancer is not clearly understood. The aim of this study was to examine the expression of these three proteins in tumor and non-tumor laryngeal tissues from patients with laryngeal squamous cell carcinoma. These three proteins were dominantly expressed in the nucleus and their levels were higher in the tumor tissue than in the non-tumor tissue, although the comparison between the tumor and non-tumor tissues of p53 staining did not reach significance. The intensity of the nuclear stain of E7 and p53 was stronger than that of p65, a subunit of NF{kappa}B. Correlation analysis revealed that there was a positive relationship between the level of HPV16 E7 and the expression of p65. The correlation between E7 and p53 was also significant, although to a lesser degree. The finding of nuclear localization of p65 suggests that NF{kappa}B is constantly activated in the laryngeal cancer cells, whereas the sequestration of p53 in the nucleus may represent a mutated form of p53, which is probably inactivated by HPV16 oncoproteins. In conclusion, this study suggests that the nuclear localization of NF{kappa}B and p53 may play a role in the development of human laryngeal squamous cell carcinoma infected with HPV16. (J Histochem Cytochem 51:533–539, 2003)

Key Words: laryngeal squamous cell, carcinoma, HPV16 E7, NF{kappa}B, p53


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
G. Sethi, B. Sung, and B. B. Aggarwal
Nuclear Factor-{kappa}B Activation: From Bench to Bedside
Experimental Biology and Medicine, January 1, 2008; 233(1): 21 - 31.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Zhang, B. Peng, and X. Chen
Expressions of Nuclear Factor {kappa}B, Inducible Nitric Oxide Synthase, and Vascular Endothelial Growth Factor in Adenoid Cystic Carcinoma of Salivary Glands: Correlations with the Angiogenesis and Clinical Outcome
Clin. Cancer Res., October 15, 2005; 11(20): 7334 - 7343.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Takada, M. Andreeff, and B. B. Aggarwal
Indole-3-carbinol suppresses NF-{kappa}B and I{kappa}B{alpha} kinase activation, causing inhibition of expression of NF-{kappa}B-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells
Blood, July 15, 2005; 106(2): 641 - 649.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2003

 
Purchase HCS Short Course Manual on HCS site