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Journal of Histochemistry and Cytochemistry, Vol. 51, 973-976, July 2003, Copyright © 2003, The Histochemical Society, Inc.

BRIEF REPORT

Localization of Thioredoxin-interacting Protein (TXNIP) mRNA in Epithelium of Human Gastrointestinal Tract

Yasuo Takahashia, Yukimoto Ishiib, Akiko Murataa, Toshihito Nagataa, and Satoshi Asaia
a Division of Genetic and Genomic Medicine, Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
b 3rd Department of Surgery, Nihon University School of Medicine, Tokyo, Japan

Correspondence to: Yasuo Takahashi, Div. of Genetic and Genomic Medicine, Medical Research Center, Nihon U. School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan. E-mail: yasuot@med.nihon-u.ac.jp

Thioredoxin-interacting protein (TXNIP) is a negative regulator of thioredoxin. However, its role in the gastrointestinal (GI) epithelium is as yet unknown. Using in situ hybridization, we demonstrated that mRNA of TXNIP was differentially expressed in the epithelium of the human GI tract. TXNIP transcript was especially prominent in terminal differentiated cells. TXNIP was also highly expressed in lymphocytes in the lymphoid follicles. Our results suggest a new potential role of TXNIP in the differentiation of epithelial cells and in mucosal immunity of the GI tract. (J Histochem Cytochem 51:973–976, 2003)

Key Words: gastrointestinal tract, in situ hybridization, mucosal immunity, VDUP1, TBP-2


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