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Journal of Histochemistry and Cytochemistry, Vol. 51, 1005-1015, August 2003, Copyright © 2003, The Histochemical Society, Inc.

ARTICLE

Cytoprotective Effects of Polyenoylphosphatidylcholine (PPC) on ß-cells During Diabetic Induction by Streptozotocin

Seung-Hee Leea, Yu-Mi Hana, Bon-Hong Minb, and In-Sun Parka
a Department of Anatomy, College of Medicine, Inha University, Inchon, Korea
b Department of Pharmacology and BK21 Program for Medical Sciences, College of Medicine, Korea University, Seoul, Korea

Correspondence to: In-Sun Park, Dept. of Anatomy, College of Medicine, Inha University, Choong-Gu, Shinheung-Dong, Inchon, 400-103, Korea. E-mail: sunpark@inha.ac.kr

Polyenoylphosphatidylcholine (PPC), a phosphatidylcholine-rich phospholipid extracted from soybean, has been reported to protect liver cells from alloxan-induced cytotoxicity. The present study aimed to investigate whether PPC protects pancreatic ß-cells from the cytotoxic injury induced by streptozotocin, thus preserving insulin synthesis and secretion. ß-Cells of the PPC-treated rats showed a significant reduction of cell death with lesser destruction of plasma membrane on streptozotocin insult. They demonstrated a rapid recovery of GLUT-2 expression, whereas almost irreversible depletion of membrane-bound GLUT-2 was seen in ß-cells of the rats treated with only streptozotocin. A similar cytoprotective effect of PPC was also monitored in the PPC-pretreated MIN6 cells. These ß-cells retained their ability to synthesize and secrete insulin and no alteration of glucose metabolism was detected. These results strongly suggest that PPC plays important roles not only in protecting ß-cells against cytotoxicity but also in maintaining their insulin synthesis and secretion for normal glucose homeostasis. (J Histochem Cytochem 51:1005–1015, 2003)

Key Words: polyenoylphosphatidylcholine, pancreas, cytoprotection, ß-cell, insulin, streptozotocin, diabetes


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