Search:        >> Advanced Search
Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pearson, R. J. Articles by Carroll, S. L. Search for Related Content PubMed PubMed Citation Articles by Pearson, R. J., Jr. Articles by Carroll, S. L. Social Bookmarking                         What's this?

ErbB Transmembrane Tyrosine Kinase Receptors Are Expressed by Sensory and Motor Neurons Projecting into Sciatic Nerve

Richard J. Pearson, Jr. and Steven L. Carroll

Departments of Pathology and Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama

Correspondence to: Dr. Steven L. Carroll, Div. of Neuropathology, Dept. of Pathology, University of Alabama at Birmingham, 1720 Seventh Avenue South, SC843, Birmingham, AL 35294-0017. E-mail: carroll{at}path.uab.edu

Adult spinal cord motor and dorsal root ganglion (DRG) sensory neurons express multiple neuregulin-1 (NRG-1) isoforms that act as axon-associated factors promoting neuromuscular junction formation and Schwann cell proliferation and differentiation. NRG-1 isoforms are also expressed by muscle and Schwann cells, suggesting that motor and sensory neurons are themselves acted on by NRG-1 isoforms produced by their peripheral targets. To test this hypothesis, we examined the expression of the NRG-1 receptor subunits erbB2, erbB3, and erbB4 in rat lumbar DRG and spinal cord. All three erbB receptors are expressed in these tissues. Sciatic nerve transection, an injury that induces Schwann cell expression of NRG-1, alters erbB expression in DRG and cord. Virtually all DRG neurons are erbB2- and erbB3-immunoreactive, with erbB4 also detectable in many neurons. In spinal cord white matter, erbB2 and erbB4 antibodies produce dense punctate staining, whereas the erbB3 antibody primarily labels glial cell bodies. Spinal cord dorsal and ventral horn neurons, including -motor neurons, exhibit erbB2, erbB3, and erbB4 immunoreactivity. Spinal cord ventral horn also contains a population of small erbB3+/S100ß+/GFAP– cells (GFAP-negative astrocytes or oligodendrocytes). We conclude that sensory and motor neurons projecting into sciatic nerve express multiple erbB receptors and are potentially NRG-1 responsive. (J Histochem Cytochem 52:1299–1311, 2004)

Key Words: neuregulin • glial growth factor • heregulin • regeneration • acetylcholine receptor-inducing • activity

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. F. McGuire, S. Rouen, E. Siegfreid, D. E. Wright, and R. T. Dobrowsky Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy Diabetes, November 1, 2009; 58(11): 2677 - 2686. [Abstract] [Full Text] [PDF]

				Y. Honjo, J. Kniss, and J. S. Eisen Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons Development, August 1, 2008; 135(15): 2615 - 2625. [Abstract] [Full Text] [PDF]

				C. R. Hayworth, S. E. Moody, L. A. Chodosh, P. Krieg, M. Rimer, and W. J. Thompson Induction of neuregulin signaling in mouse schwann cells in vivo mimics responses to denervation. J. Neurosci., June 21, 2006; 26(25): 6873 - 6884. [Abstract] [Full Text] [PDF]

				S. Atanasoski, S. S. Scherer, E. Sirkowski, D. Leone, A. N. Garratt, C. Birchmeier, and U. Suter ErbB2 Signaling in Schwann Cells Is Mostly Dispensable for Maintenance of Myelinated Peripheral Nerves and Proliferation of Adult Schwann Cells after Injury J. Neurosci., February 15, 2006; 26(7): 2124 - 2131. [Abstract] [Full Text] [PDF]

				R. T. Dobrowsky, S. Rouen, and C. Yu Altered Neurotrophism in Diabetic Neuropathy: Spelunking the Caves of Peripheral Nerve J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 485 - 491. [Abstract] [Full Text] [PDF]

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact

The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2004