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Journal of Histochemistry and Cytochemistry
Volume 52 (2): 153-156, 2004
Copyright ©The Histochemical Society, Inc.

RAPID COMMUNICATION

Laminins {alpha}2 and {alpha}4 in Pancreatic Acinar Basement Membranes Are Required for Basal Receptor Localization

Jeffrey H. Miner, Cong Li and Bruce L. Patton

Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, Missouri (JHM,CL), and CROET, Oregon Health Sciences University, Portland, Oregon (BLP)

Correspondence to: Jeffrey H. Miner, Renal Division, Box 8126, Washington U. School of Medicine, 660 South Euclid Ave., St Louis, MO 63110. E-mail: minerj{at}wustl.edu

Basement membranes (BMs) are thin layers of extracellular matrix (ECM) found at the basal surface of many cell types, including epithelial cells. BMs present growth, differentiation, and anti-apoptotic signals and provide structural support to cells, compartmentalize tissues, and serve as filters. The structure and function of BMs depend on their complement of laminins, a family of {alpha}ß{gamma} heterotrimeric glycoproteins. We found that laminins containing the {alpha}2 and {alpha}4 chains are the major laminins in pancreatic acinar BMs. Importantly, these laminins were required for proper basal localization on acinar cells of two laminin receptors, dystroglycan and integrin {alpha}6ß4. (J Histochem Cytochem 52:153–156, 2004)

Key Words: laminin • integrin • pancreas • merosin • dystroglycan


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