Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dietrich, W.
Right arrow Articles by Reiter, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dietrich, W.
Right arrow Articles by Reiter, W. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry
Volume 52 (3): 355-360, 2004
Copyright ©The Histochemical Society, Inc.

Expression of Estrogen Receptors in Human Corpus Cavernosum and Male Urethra

Wolf Dietrich, Andrea Haitel, Johannes C. Huber and Werner J. Reiter

Division of Gynecologic Endocrinology and Reproductive Medicine (WD,JCH), University of Vienna Medical School, Vienna, Austria; Department of Clinical Pathology (AH), University of Vienna Medical School, Vienna, Austria; and Department of Urology (WJR), Korneuburg Hospital, Korneuburg, Austria

Correspondence to: Wolf Dietrich, MD, Div. of Gynecologic Endocrinology and Reproductive Medicine, Univ. of Vienna Medical School, Waehringer Guertel 18–20, 1090 Vienna, Austria. E-mail: wolf.dietrich{at}akh-wien.ac.at

Estrogen, largely produced in testis and adrenal gland, may play important roles in male reproduction. Most of the effects of estrogens are mediated by binding of estrogen to one or both of the two estrogen receptor (ER) subtypes {alpha} and ß. Recently, they have been described in testis, prostate, and efferent ducts, mostly in rodents. The goal of this study was to prove the evidence of ERs in human corpus cavernosum and male urethra, exploring the protein expression of these receptors by immunohistochemistry. Corpus cavernosum and corpus spongiosum smooth muscle was immunoreactive for the androgen receptor (AR), ER{alpha}, and strongly for ERß. Endothelial cells were negative for AR, sporadically positive for ER{alpha}, and positive for ERß. Urethral epithelium showed strong nuclear expression of AR, predominantly in the basal cell layer, and nuclear expression of ER{alpha} in the intermediate cells. ERß was highly expressed in almost all urethral nuclei and, much more weakly, in cytoplasm. Progesterone receptor (PGR) was negative in all cases and all tissues. These results represent the first report that ER{alpha} and particularly ERß are regularly expressed in human penile tissue. (J Histochem Cytochem 52:355–360, 2004)

Key Words: estrogen receptor-{alpha} • estrogen receptor-ß • androgen receptor • corpus cavernosum • endothelium • urethra


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
S. Ban, F. Sata, N. Kurahashi, S. Kasai, K. Moriya, H. Kakizaki, K. Nonomura, and R. Kishi
Genetic polymorphisms of ESR1 and ESR2 that may influence estrogen activity and the risk of hypospadias
Hum. Reprod., June 1, 2008; 23(6): 1466 - 1471.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
A. Beleza-Meireles, V. Tohonen, C. Soderhall, C. Schwentner, C. Radmayr, I. Kockum, and A. Nordenskjold
Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias
Eur. J. Endocrinol., May 1, 2008; 158(5): 729 - 739.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Beleza-Meireles, I. Kockum, F. Lundberg, C. Soderhall, and A. Nordenskjold
Risk Factors for Hypospadias in the Estrogen Receptor 2 Gene
J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3712 - 3718.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
H O Goyal, T D Braden, C S Williams, and J W Williams
Role of estrogen in induction of penile dysmorphogenesis: a review
Reproduction, August 1, 2007; 134(2): 199 - 208.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
H O Goyal, T D Braden, P S Cooke, M A Szewczykowski, C S Williams, P Dalvi, and J W Williams
Estrogen receptor-{alpha} mediates estrogen-inducible abnormalities in the developing penis
Reproduction, May 1, 2007; 133(5): 1057 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Watanabe, R. Yoshida, K. Ueoka, K. Aoki, I. Sasagawa, T. Hasegawa, K. Sueoka, N. Kamatani, Y. Yoshimura, and T. Ogata
Haplotype analysis of the estrogen receptor 1 gene in male genital and reproductive abnormalities
Hum. Reprod., May 1, 2007; 22(5): 1279 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
W. Dietrich, A. Haitel, G. Holzer, J. C. Huber, A. Kolbus, and W. Tschugguel
Estrogen Receptor-{beta} Is the Predominant Estrogen Receptor Subtype in Normal Human Synovia
Reproductive Sciences, October 1, 2006; 13(7): 512 - 517.
[Abstract] [PDF]

Home page
 J Mol EndocrinolHome page
S Jesmin, C N Mowa, I Sakuma, N Matsuda, H Togashi, M Yoshioka, Y Hattori, and A Kitabatake
Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood
J. Mol. Endocrinol., October 1, 2004; 33(2): 343 - 359.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2004