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Journal of Histochemistry and Cytochemistry
Volume 52 (3): 419-422, 2004
Copyright ©The Histochemical Society, Inc.

BRIEF REPORT

Immunohistochemical Analysis of Advanced Human Breast Carcinomas Reveals Downregulation of Protein Kinase C{alpha}

Christopher Kerfoot, Weidong Huang and Susan A. Rotenberg

IMPATH Predictive Oncology, Inc., Los Angeles, California (CK,WH), and Department of Chemistry & Biochemistry, Queens College of CUNY, Flushing, New York (SAR)

Correspondence to: Susan A. Rotenberg, Dept. of Chemistry & Biochemistry, Queens College of CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367. E-mail: susan_rotenberg{at}qc.edu

Forty-six advanced-stage human breast carcinoma specimens were evaluated by immunohistochemistry for PKC{alpha} expression and compared with 25 samples of normal adjacent breast tissue. For normal tissue, the median staining of ductal epithelia was of moderate intensity. No staining was observed for 67% of tumor specimens, and only 4% showed intensities greater than the median observed in normal tissue. Faint to moderate PKC{alpha} staining was observed in the stroma, inflammatory cells, and fibroblasts of tumors but was absent in normal tissue. These findings demonstrate that downregulation of PKC{alpha} protein occurs in epithelial cells of advanced breast tumors (p<0.001).

(J Histochem Cytochem 52:419–422, 2004)

Key Words: isoform • epithelial • antibody • tissue


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