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DOI: 10.1369/jhc.4A6267.2004
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Journal of Histochemistry and Cytochemistry
Volume 52 (6): 789-795, 2004
Copyright ©The Histochemical Society, Inc.

Presence of Collagen IV in the Ciliary Zonules of the Human Eye : An Immunohistochemical Study by LM and TEM

Leonoor I. Los, Roelofje J. van der Worp, Marja J.A. van Luyn and Johanna M.M. Hooymans

University Hospital/University of Groningen, Department of Ophthalmology (LIL,RJvdW,JMMH), and University of Groningen, Department of Pathology and Laboratory Medicine, Section of Medical Biology (RJvdW,MJAvL), Groningen, The Netherlands

Correspondence to: Leonoor I. Los, University Hospital/University of Groningen, Dept.of Ophthalmology, PO Box 30,001, 9700 RB Groningen, The Netherlands. E-mail: l.i.los{at}ohk.azg.nl

The ciliary zonules of the eye are composed of fibrillar and non-fibrillar components. Fibrils provide tensile strength and elasticity, whereas non-fibrillar components serve as a coating surrounding the fibrils. This coating behaves as a barrier to macromolecules. The present light and transmission electron microscopic (LM and TEM) study identified collagen IV as a novel component of this coating. Collagen IV was demonstrated by pre-embedding and postembedding immunohistochemical (IHC) techniques using monoclonal and polyclonal antibodies. The specificity of the polyclonal anticollagen IV antibody was verified by ELISA. (J Histochem Cytochem 52:789–795, 2004)

Key Words: collagen IV • ciliary zonules • immunohistochemistry


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