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DOI: 10.1369/jhc.4A6279.2004
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Journal of Histochemistry and Cytochemistry
Volume 52 (7): 967-977, 2004
Copyright ©The Histochemical Society, Inc.

Corticotropin-releasing Factor 2 Receptor Localization in Skeletal Muscle

Steven Samuelsson1, Jana S. Lange, Richard T. Hinkle, Mark Tarnopolsky and Robert J. Isfort

Research Division, Procter & Gamble Pharmaceuticals, Mason, Ohio (SS,JSL,RTH,RJI), and Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada (MT)

Correspondence to: Dr. Robert J. Isfort, Research Division, Procter & Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason–Montgomery Road, Mason, OH 45040-9317. E-mail: isfort.rj{at}pg.com

Our objective in this study was to localize the corticotropin-releasing factor 2 receptor (CRF2R) in rodent and human skeletal muscle. We found CRF2R protein to be abundant in neural tissues in skeletal muscle, including large nerve fibers and bundles, neural tissue associated with mechanoreceptors, muscle spindles, and the Golgi tendon organ. CRF2R protein was also abundant in blood vessels in skeletal muscle. CRF2R protein was also observed, although with less abundance, in the endo/perimysial regions in skeletal muscle. The localization of the CRF2R to blood vessels is consistent with the CRF2R-mediated vascular phenomena observed previously, but the observation of CRF2R in neural tissue in skeletal muscle is a novel finding with an unknown function.

(J Histochem Cytochem 52:967–977, 2004)

Key Words: corticotropin-releasing factor • receptor • skeletal muscle • neural tissues


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