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DOI: 10.1369/jhc.4A6253.2004
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Journal of Histochemistry and Cytochemistry
Volume 52 (8): 1073-1081, 2004
Copyright ©The Histochemical Society, Inc.

Differential Expression of Basement Membrane Components in Lymphatic Tissues

Marko Määttä, Annikki Liakka, Sirpa Salo, Kaisa Tasanen, Leena Bruckner-Tuderman and Helena Autio-Harmainen

Departments of Pathology (MM,AL,HA-H) and Biochemistry (SS), University of Oulu, Oulu, Finland; Clinic of Dermatology (KT), University Hospital of Oulu, Oulu, Finland; and Department of Dermatology, University of Freiburg, Freiburg, Germany (LB-T)

Correspondence to: Marko Määttä, MD, PhD, Dept. of Ophthalmology, University of Helsinki, PO Box 220, 00029 HUS, Helsinki, Finland. E-mail: mmaatta{at}mailcity.com

Peripheral lymphoid tissues act as important organs of immunological defense. Characteristic of their architecture is the rich reticular fiber meshwork composed of various extracellular matrix (ECM) molecules with which the stationary non-lymphatic cells stay in intimate contact and form channels through which the lymphatic cells travel. Here we studied the distribution of various laminin (Ln) chains and different types of collagens in human spleen, lymph node, and tonsil to clarify their chain-specific distribution. The most widely distributed proteins in all these organs were Ln chains {alpha}5, ß1, {gamma}1 and collagen types IV and XVIII, which were present in practically all compartments. Conversely, Ln {alpha}1, {alpha}2, {alpha}4, and type VII collagen showed a more restricted expression pattern. A unique feature was that Ln {alpha}3-, ß3-, and {gamma}2-chains, which normally are not localized to the vascular wall in non-lymphatic tissues, were present also in capillary basement membranes (BMs) of the follicular structures of lymph node and tonsil and in Ln {alpha}1-chain and type VII collagen also in the splenic white pulp. We also found that collagen XVII was exclusively present in the ring fibers of the spleen. The results indicate that BMs of lymphatic tissues contain a variety of macromolecules that probably contribute strongly to immunological events. In addition, capillaries of the lymphoid tissue exhibit a specified BM composition resembling that in epithelial BMs of non-lymphoid tissues. (J Histochem Cytochem 52:1073–1081, 2004)

Key Words: collagen • endothelium • laminin • reticular fiber • ring fiber


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