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DOI: 10.1369/jhc.4A6474.2005
Volume 53 (2): 187-196, 2005
Copyright ©The Histochemical Society, Inc.
Muscular ETB Receptors Develop Postnatally and Are Differentially Distributed in Specific Segments of the Rat Vasculature
Department of Anesthesiology and Intensive Care Medicine, Technical University of Dresden, Dresden, Germany (MW,LK,TK); Institute of Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany (WK); and Department of Anesthesiology and Intensive Care Medicine, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany (JS)
Correspondence to: Martina Wendel, Department of Anesthesiology and Intensive Care Medicine, University Hospital Dresden, Technical University of Dresden, Fetscherstr. 74, D-01307 Dresden, Germany. E-mail: wendwell{at}rcs.urz.tu-dresden.de
The endothelin/endothelin–receptor system is a key player in the regulation of vascular tone in mammals. We raised and characterized an antiserum against rat ETB receptor and investigated the distribution of ETB receptors in different vascular beds during postnatal development (day 0 through day 28) and in the adult rat. We report the tissue-specific and age-dependent presence of vasoconstrictor ETB receptors. At the time of birth, vascular smooth muscle cells from all tissues examined did not exhibit ETB receptor immunoreactivity. The occurrence of ETB receptor immunoreactivity in the postnatal development was time dependent and started in small coronary and meningeal arteries at day 5, followed by small mesenteric arteries as well as brachial artery and vein at day 14. At day 21, ETB receptors were present in the media of muscular segments of pulmonary artery, large coronary arteries, and intracerebral arterioles. At day 28, ETB receptor immunoreactivity was evident in interlobular renal arteries, vas afferens, and efferens. Large renal arteries, mesenteric artery, and elastic segments of pulmonary arteries, as well as coronary and mesenteric veins, did not exhibit ETB receptor immunoreactivity. These data demonstrate the age-dependent and tissue-specific presence of ETB receptors, mainly on arterial smooth muscle cells in the vascular system of the rat. (J Histochem Cytochem 53:187–196, 2005)
Key Words: endothelin • endothelinB receptor • rat • postnatal development • heart • lung • kidney
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