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DOI: 10.1369/jhc.4B6509.2005
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Journal of Histochemistry and Cytochemistry
Volume 53 (3): 273-276, 2005
Copyright ©The Histochemical Society, Inc.

BRIEF REPORT

Topology of Chromosomes 18 and X in Human Blastomeres from 3- to 4-Day-old Embryos

Jan Diblík, Milan Macek, Sr, Maria-Cristina Magli, Roman Krejcí and Luca Gianaroli

Center of Reproductive Genetics, Institute of Biology and Medical Genetics, Charles University, 2nd School of Medicine, University Hospital Motol, Prague, Czech Republic (JD,MM); Società Italiana Studi di Medicina della Riproduzione, Bologna, Italy (MCM,LG); and Department of Genetics and Microbiology, Charles University, Faculty of Science, Prague, Czech Republic (RK)

Correspondence to: Milan Macek Sr., Institute of Biology and Medical Genetics, University Hospital Motol, V Úvalu 84, Prague 5 CZ-150 06, Czech Republic. E-mail: pavel.roubic{at}lfmotol.cuni.cz

The positions of chromosomes 18 and X fluorescence in situ hybridization signals were analyzed in blastomeres generated from human in vitro fertilization 3- to 4-day-old embryos after preimplantation screening of aneuploidy of chromosomes 13, 16, 18, 21, 22, X, and Y. Fluorescent signal localization compared with a three-dimensional sphere model of random signal distribution revealed significant differences, providing evidence of peripheral localization of chromosome 18 in aneuploid (p=0.0013) and aneuploid/euploid blastomeres (p=0.0011). No differences were found in localization of chromosome 18 in euploid and in chromosome X in euploid and aneuploid blastomeres.

(J Histochem Cytochem 53:273–276, 2005)

Key Words: chromosome localization • FISH • chromosome 18 • chromosome X • human blastomeres


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