Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
DOI: 10.1369/jhc.4B6509.2005
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Diblík, J.
Right arrow Articles by Gianaroli, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diblík, J.
Right arrow Articles by Gianaroli, L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry
Volume 53 (3): 273-276, 2005
Copyright ©The Histochemical Society, Inc.

BRIEF REPORT

Topology of Chromosomes 18 and X in Human Blastomeres from 3- to 4-Day-old Embryos

Jan Diblík, Milan Macek, Sr, Maria-Cristina Magli, Roman Krejcí and Luca Gianaroli

Center of Reproductive Genetics, Institute of Biology and Medical Genetics, Charles University, 2nd School of Medicine, University Hospital Motol, Prague, Czech Republic (JD,MM); Società Italiana Studi di Medicina della Riproduzione, Bologna, Italy (MCM,LG); and Department of Genetics and Microbiology, Charles University, Faculty of Science, Prague, Czech Republic (RK)

Correspondence to: Milan Macek Sr., Institute of Biology and Medical Genetics, University Hospital Motol, V Úvalu 84, Prague 5 CZ-150 06, Czech Republic. E-mail: pavel.roubic{at}lfmotol.cuni.cz

The positions of chromosomes 18 and X fluorescence in situ hybridization signals were analyzed in blastomeres generated from human in vitro fertilization 3- to 4-day-old embryos after preimplantation screening of aneuploidy of chromosomes 13, 16, 18, 21, 22, X, and Y. Fluorescent signal localization compared with a three-dimensional sphere model of random signal distribution revealed significant differences, providing evidence of peripheral localization of chromosome 18 in aneuploid (p=0.0013) and aneuploid/euploid blastomeres (p=0.0011). No differences were found in localization of chromosome 18 in euploid and in chromosome X in euploid and aneuploid blastomeres.

(J Histochem Cytochem 53:273–276, 2005)

Key Words: chromosome localization • FISH • chromosome 18 • chromosome X • human blastomeres


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
K. A. Finch, G. Fonseka, D. Ioannou, N. Hickson, Z. Barclay, K. Chatzimeletiou, A. Mantzouratou, A. Handyside, J. Delhanty, and D. K. Griffin
Nuclear organisation in totipotent human nuclei and its relationship to chromosomal abnormality
J. Cell Sci., March 1, 2008; 121(5): 655 - 663.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2005