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DOI: 10.1369/jhc.4B6510.2005
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Journal of Histochemistry and Cytochemistry
Volume 53 (3): 371-373, 2005
Copyright ©The Histochemical Society, Inc.

BRIEF REPORT

QF-PCR Examination of Parental and Meiotic Origin of Trisomy 21 in Central and Eastern Europe

Marina Machatkova, Martina Brouckova, Milada Matejckova, Alice Krebsova, Karl Sperling, Svetlana Vorsanova, Sergei Kutsev, Tatiana Zerova, Svetlana Arbuzova, Roman Krejci, Michael Petersen and Milan Macek, Sr.

Institute of Biology and Medical Genetics, University Hospital Motol, Charles University, Second Medical School, Prague, Czech Republic (MM,MB,AK,MM,MM); Institute of Human Genetics, Charité, Universitaetsmedizin Berlin, Berlin, Germany (AK,KS); Molecular Cytogenetic Laboratory, Institute of Pediatrics and Children Surgery, Ministry of Health, Moscow, Russia (SV); Centre of Clinical Morphology and Genetics, Rostov State Medical University, Ministry of Health, Rostov, Russia (SK); Genetic Department of Institute of Medical Improvement, Kiev, Ukraine (TZ); Interregional Medico-Genetics Centre, Central Hospital Clinic No. 1, Donetsk, Ukraine (SA); Institute of Child Health, Athens, Greece (MP); and Department of Genetics and Microbiology, Charles University, Faculty of Science, Prague, Czech Republic (RK)

Correspondence to: Milan Macek Sr., University Hospital Motol, Institute of Biology and Medical Genetics, Laboratory of Assisted Reproduction and Reproductive Genetics, V Úvalu 84, Prague–5, 150 06, Czech Republic. E-mail: pavel.roubic{at}lfmotol.cuni.cz

Study of parental/meiotic origin of free trisomy 21 in nuclear families from Russia (70 cases), Ukraine (32 cases), and 22 from Germany revealed maternal nondisjunction in 77.3% (Germany), 93.8% (Ukraine), and 91.4% (Russia), paternal origin in 13.6%, 6.2%, and 8.6%, respectively. Maternal meiosis I errors were found in 84.4% (Ukraine), 77.1% (Russia), paternal origin in 3.1% (Ukraine), 2.9% (Russia). Maternal meiosis II errors occurred in 9.4% and 14.3% and paternal in 3.1% and 5.7% in Ukraine and Russia, respectively. No significant differences were found in maternal/paternal origin among Ukraine, Russia, Germany, and published data from other European regions.

(J Histochem Cytochem 53:371–373, 2005)

Key Words: quantitative fluorescent PCR • trisomy 21 • parental/meiotic origin • Ukraine • Russia


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