Journal of Histochemistry and Cytochemistry
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DOI: 10.1369/jhc.4B6427.2005
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Journal of Histochemistry and Cytochemistry
Volume 53 (3): 381-384, 2005
Copyright ©The Histochemical Society, Inc.

BRIEF REPORT

First Systematic CGH-based Analyses of Ancient DNA Samples of Malformed Fetuses Preserved in the Meckel Anatomical Collection in Halle/Saale (Germany)

H. Tönnies, A. Gerlach, R. Klunker, R. Schultka and L. Göbbel

Institut für Humangenetik, Chromosomendiagnostik und Molekuluare Zytogenetik, Charité, Campus Virchow Klinikum, Humboldt-Universität Berlin, Berlin, Germany (HT,AG), and Institut für Anatomie und Zellbiologie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (RK,RS,LG)

Correspondence to: H. Tönnies, Institut für Humangenetik, Campus Virchow Klinikum, Charité, Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. E-mail: holger.toennies{at}charite.de

We present the first data on our comparative genomic hybridization (CGH)–based strategy for the analysis of ancient DNA (aDNA) samples extracted from fetuses preserved in the Meckel Anatomical Collection in Halle, Germany. The collection contains numerous differently fixed ancient samples of fetal malformations collected from the middle of the 18th to the early 19th century. The main objective of this study is to establish a "standard" aDNA extraction and amplification protocol as a prerequisite for successful CGH analyses to detect or exclude chromosomal imbalances possibly causative for the malformations described for the fetuses. (J Histochem Cytochem 53:381–384, 2005)

Key Words: ancient DNA • Meckel Anatomical Collection • comparative genomic • hybridization • polymerase chain reaction


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