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Co-accumulation of Dendritic Cells and Natural Killer T Cells within Rupture-prone Regions in Human Atherosclerotic Plaques

Yuri V. Bobryshev and Reginald S.A. Lord

Surgical Professorial Unit, St. Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia

Correspondence to: Dr. Yuri V. Bobryshev, Surgical Professorial Unit, Level 5, DeLacy Building, St. Vincent's Hospital, Sydney, Darlinghurst, NSW 2010 Australia. E-mail: ybobryshev{at}stvincents.com.au

We previously reported that CD1d, a molecule responsible for the presentation of lipid antigens, is expressed in atherosclerotic lesions and that its expression is restricted to dendritic cells. Recent studies demonstrating that CD1d-restricted natural killer T (NKT) cells are involved in atherogenesis prompted the present study investigating whether NKT cells are present in human atherosclerotic lesions and, if so, whether there is an association between NKT cells and dendritic cells. We found that NKT cells do accumulate in rupture-prone shoulders of atherosclerotic plaques and observed direct contacts of dendritic cells with NKT cells in rupture-prone regions of plaque.

(J Histochem Cytochem 53:781–785, 2005)

Key Words: arteries • atherosclerosis • dendritic cells • NKT cells

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