Journal of Histochemistry and Cytochemistry
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DOI: 10.1369/jhc.4B6522.2005
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Journal of Histochemistry and Cytochemistry
Volume 53 (6): 799-801, 2005
Copyright ©The Histochemical Society, Inc.

BRIEF REPORT

Immunohistochemical Detection of the ß4 Integrin Subunit in Pancreatic Adenocarcinoma

Brianna Gleason, Brian Adley, M. Sambasiva Rao and Leslie K. Diaz

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Correspondence to: Leslie K. Diaz, MD, Department of Surgical Pathology, Northwestern Memorial Hospital, 251 E. Huron St., Feinberg 7-325, Chicago, IL. E-mail: l-diaz{at}northwestern.edu

The expression of the ß4 integrin subunit protein in pancreatic cancer was investigated using routine immunohistochemical methods on paraffin-embedded archival material. Forty-eight cases of pancreatic ductal adenocarcinoma were immunostained with a monoclonal antibody to the ß4 integrin subunit, and the extent of staining was compared with that seen in non-cancerous pancreatic tissues, including 15 separate cases of chronic pancreatitis and 6 sections from normal pancreas. We found that the ß4 integrin subunit protein was overexpressed in the majority of pancreatic carcinoma cases tested, whereas chronic pancreatitis and normal pancreas did not display substantial levels of expression. (J Histochem Cytochem 53:799–801, 2005)

Key Words: {alpha}6ß4 integrin • pancreatic cancer • immunohistochemistry


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