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Originally published as JHC exPRESS on May 27, 2005.
doi:10.1369/jhc.5R6647.2005
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Journal of Histochemistry and Cytochemistry
Volume 53 (9): 1043-1070, 2005
Copyright ©The Histochemical Society, Inc.

REVIEW

Ultrastructural Studies of Human Basophils and Mast Cells

Ann M. Dvorak

Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts

Correspondence to: Ann M. Dvorak, MD, Department of Pathology/East Campus, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215. E-mail: advorak{at}bidmc.harvard.edu

Ultrastructural studies of human mast cells (HMCs) and basophils (HBs) are reviewed. Sources of HMCs include biopsies of tissue sites and in situ study of excised diseased organs; isolated, partially purified samples from excised organs; and growth-factor-stimulated mast cells that develop de novo in cultures of cord blood cells. Sources of HBs for study include partially purified peripheral blood basophils, basophils in tissue biopsies, and specific growth factor-stimulated basophils arising de novo from cord blood cells. The ultrastructural studies reviewed deal with identity, secretion, vesicles, recovery, and synthesis issues related to the biology of these similar cells.

(J Histochem Cytochem 53:1043–1070, 2005)

Key Words: basophil • mast cell • ultrastructure • secretion • vesicle transport • piecemeal degranulation • recovery from degranulation • synthesis • granules • lipid bodies


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