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Originally published as JHC exPRESS on May 27, 2005.
doi:10.1369/jhc.4A6588.2005
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Journal of Histochemistry and Cytochemistry
Volume 53 (9): 1139-1147, 2005
Copyright ©The Histochemical Society, Inc.

Immunoreactivity of the Septins SEPT4, SEPT5, and SEPT8 in the Human Eye

Mona Pache, Barbara Zieger, Susanne Bläser and Peter Meyer

University Eye Clinic (MP) and Department of Pediatrics and Adolescent Medicine (BZ,SB), University of Freiburg, Freiburg, Germany, and University Eye Clinic, Department of Ophthalmopathology, Basel, Switzerland (PM)

Correspondence to: Mona Pache, MD, Universitäts-Augenklinik Freiburg, Killianstr. 5, 79106 Freiburg, Germany. E-mail: pache{at}aug.ukl.uni-freiburg.de

We aimed to examine the distribution of SEPT4, SEPT5, and SEPT8 in the human eye. For each septin, five to six normal human eyes were examined by immunohistochemical staining of paraffin sections using polyclonal antibodies against SEPT4, SEPT5, and SEPT8 and an avidin biotin complex immunodetection system. SEPT4 immunoreactivity (IR) was detected primarily in the epithelium of cornea, lens, and nonpigmented ciliary epithelium; in the endothelium of cornea and vessels of iris and retina; and in the retinal nerve fiber layer, the outer plexiform layer, the outer segments of the photoreceptor cells, the inner limiting membrane of the optic nerve head, and optic nerve axons. SEPT5-IR was present in corneal endothelial cells, iris tissue, nonpigmented ciliary epithelium, and epithelial cells of the lens. SEPT8-IR almost paralleled that of SEPT4, except for a lower SEPT8-IR of the outer photoreceptor segments and a positive staining of the meningothelial cell nests in the subarachnoidal space of the bulbar segment of the orbital optic nerve. In conclusion, SEPT4, SEPT5, and SEPT8 are expressed in various ocular tissues, each revealing a distinct expression pattern. Both physiological and potential pathophysiological role of septins in the human eye deserve further investigation. (J Histochem Cytochem 53:1139–1147, 2005)

Key Words: septin • SEPT4 • SEPT5 • SEPT8 • human eye • cornea • ciliary body • trabecular meshwork • retina • optic nerve head


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X. Xin, M. Pache, B. Zieger, I. Bartsch, C. Prunte, J. Flammer, and P. Meyer
Septin Expression in Proliferative Retinal Membranes
J. Histochem. Cytochem., November 1, 2007; 55(11): 1089 - 1094.
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