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Distribution of Endothelin Receptor Subtypes ET_A and ET_B in the Rat Kidney

Martina Wendel, Lilla Knels, Wolfgang Kummer and Thea Koch

Department of Anesthesiology and Intensive Care Medicine, University Hospital, Dresden, Germany (MW,LK,TK), and Institute of Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany (WK)

Correspondence to: Martina Wendel, Department of Anesthesiology and Intensive Care Medicine, Medical Faculty of the Technical University of Dresden, Fetscherstr. 74, D-01307 Dresden, Germany. E-mail: martina.wendel{at}tu-dresden.de

The endothelin (ET) receptor system is markedly involved in the regulation of renal function under both physiological and pathophysiological conditions. The present study determined the detailed cellular localization of both ET receptor subtypes, ET_A and ET_B, in the vascular and tubular system of the rat kidney by immunofluorescence microscopy. In the vascular system we observed both ET_A and ET_B receptors in the media of interlobular arteries and afferent and efferent arterioles. In interlobar and arcuate arteries, only ET_A receptors were present on vascular smooth muscle cells. ET_B receptor immunoreactivity was sparse on endothelial cells of renal arteries, whereas there was strong labeling of peritubular and glomerular capillaries as well as vasa recta endothelium. ET_A receptors were evident on glomerular mesangial cells and pericytes of descending vasa recta bundles. In the renal tubular system, ET_B receptors were located in epithelial cells of proximal tubules and inner medullary collecting ducts, whereas ET_A receptors were found in distal tubules and cortical collecting ducts. Distribution of ET_A and ET_B receptors in the vascular and tubular system of the rat kidney reported in the present study supports the concept that both ET receptor subtypes cooperate in mediating renal cortical vasoconstriction but exert differential and partially antagonistic effects on renal medullary function. (J Histochem Cytochem 54:1193–1203, 2006)

Key Words: endothelin-1 • ET_A receptor • ET_B receptor • rats • kidney • immunohistochemistry

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