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Originally published as JHC exPRESS on July 11, 2006.
doi:10.1369/jhc.6A6923.2006
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Journal of Histochemistry and Cytochemistry
Volume 54 (12): 1327-1333, 2006
Copyright ©The Histochemical Society, Inc.

SOX13 Exhibits a Distinct Spatial and Temporal Expression Pattern During Chondrogenesis, Neurogenesis, and Limb Development

Yi Wang, Sika Ristevski and Vincent R. Harley

Human Molecular Genetics Laboratory, Prince Henry's Institute of Medical Research, Victoria, Australia (YW,VRH); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia (YW); and Monash Institute of Medical Research, Monash University, Victoria, Australia (SR)

Correspondence to: Vincent R. Harley, Human Molecular Genetics Lab, Level 3, Block E, Prince Henry's Institute of Medical Research, 246 Clayton Rd, Victoria 3168, Australia. E-mail: Vincent.Harley{at}phimr.monash.edu.au

SOX13 is a member of the SOX family of transcription factors. SOX proteins play essential roles in development, and some are associated with human genetic diseases. SOX13 maps to a multi-disease locus on chromosome 1q31–32, yet its function is unknown. Here we describe the temporal and spatial expression of SOX13 protein during mouse organogenesis. SOX13 is expressed in the three embryonic cell lineages, suggesting that it may direct various developmental processes. SOX13 is expressed in the developing central nervous system including the neural tube and the developing brain. Expression is also detected in the condensing mesenchyme and cartilage progenitor cells during endochondral bone formation in the limb as well as the somite sclerotome and its derivatives. SOX13 is also detected in the developing kidney, pancreas, and liver as well as in the visceral mesoderm of the extra-embryonic yolk sac and spongiotrophoblast layer of the placenta. J Histochem Cytochem 54:1327–1333, 2006)

Key Words: SOX13 • mouse embryonic development • expression pattern • neural tube • endochondral bone • sclerotome • visceral mesoderm • spongiotrophoblast


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