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Originally published as JHC exPRESS on April 3, 2006.
doi:10.1369/jhc.5A6869.2006
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Journal of Histochemistry and Cytochemistry
Volume 54 (8): 897-904, 2006
Copyright ©The Histochemical Society, Inc.

Caveolin-1 Expression Is Associated with Plaque Formation in Hypercholesterolemic Rabbits

Wei-Wen Lin, Yu-Chun Lin, Ti-Yu Chang, Shu-Huai Tsai, Hon-Chun Ho, Ying-Tsung Chen and Vivian C. Yang

Department of Life Science, Tunghai University, Taichung, Taiwan, Republic of China (W-WL,Y-CL,S-HT,H-CH,VCY), and Division of Cardiology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China (W-WL,T-YC,H-CH,Y-TC)

Correspondence to: Vivian C. Yang, Department of Life Science, Tunghai University, 181, Section 3, Taichung Harbor Road, Taichung, Taiwan, R.O.C. E-mail: vcyang{at}thu.edu.tw

Caveolin-1, the major structural protein of caveolae, is present in several cell types known to play a role in the development of atherosclerosis. In this study, the distribution and expression of caveolin-1 in the arterial walls were studied in hypercholesterolemic rabbits. Immunohistochemical results indicated that the staining intensity of caveolin-1 reached a high level in the arterial intima at 5 weeks after high-cholesterol-diet treatment and decreased to a very low level at 8 weeks when atheromatous plaques appeared. Western blot analysis showed that in rabbits fed a high-cholesterol diet for 5 weeks, the expression of caveolin-1 reached its highest level and then decreased from 8 to 12 weeks. The proliferative activity of smooth muscle cells (SMCs) decreased to the lowest level at 5 weeks and then increased at 8 and 12 weeks. Nitric oxide synthase activity gradually decreased in animals fed a high-cholesterol diet throughout the experiment. These studies demonstrate that the change in abundance of caveolin-1 is associated with SMC proliferation in the formation of atheromatous plaque after hypercholesterolemia insult. (J Histochem Cytochem 54:897–904, 2006)

Key Words: caveolin-1 • hypercholesterolemia • atheroma • smooth muscle cell proliferation • nitric oxide synthase activity


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