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Originally published as JHC exPRESS on March 19, 2007.
doi:10.1369/jhc.6A7151.2007
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Journal of Histochemistry and Cytochemistry
Volume 55 (7): 701-708, 2007
Copyright ©The Histochemical Society, Inc.

Expression and Localization of SWAP-70 in Human Fetomaternal Interface and Placenta During Tubal Pregnancy and Normal Placentation

Jing Liu, Dong Li, Bin Cao, Yu-xia Li, Riitta Herva, Yun-shang Piao and Yan-ling Wang

State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China (JL,DL,BC,YL,YP,YW), and Department of Pathology, University of Oulu Central Hospital, Oulu, Finland (RH)

Correspondence to: Dr. Yan-ling Wang, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 25 Bei Si Huan Xi Road, Beijing 100080, China. E-mail: wangyl{at}ioz.ac.cn

SWAP-70 has been demonstrated as a multiple functional signaling protein involved in formation of membrane ruffling induced by signal cascade of tyrosine kinase growth factor receptors. In the present study, the spatial and temporal expression pattern of SWAP-70 on human fetomaternal interface was investigated using specimens collected from tubal and normal pregnancies by in situ hybridization, immunohistochemistry, and Western blotting. Data showed an intense expression of SWAP-70 in trophoblasts at weeks 3–6 of fallopian implantation and at weeks 6–7 of normal pregnancy. The most intense expression was exhibited by those highly motile and invasive extravillous trophoblasts. From gestational week 8 on, the level of SWAP-70 in trophoblasts decreased significantly, and the signal was restricted in villous cytotrophoblast cells. In the in vitro cultured human trophoblast cell line, B6Tert-1, colocalization of SWAP-70 with F-actin was verified. Data in human placenta were similar to what we recently reported on rhesus monkey fetomaternal interface. Our results suggest that SWAP-70 may be involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation in primates. (J Histochem Cytochem 55:701–708, 2007)

Key Words: SWAP-70 • trophoblast • tubal pregnancy • F-actin


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