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Originally published as JHC exPRESS on April 16, 2007.
doi:10.1369/jhc.7A7184.2007
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Journal of Histochemistry and Cytochemistry
Volume 55 (8): 845-852, 2007
Copyright ©The Histochemical Society, Inc.

Immunohistochemical Localization of Cadherin and Catenin Adhesion Molecules in the Murine Growth Plate

H. Wayne Sampson, Alaina C. Dearman, Adebayo D. Akintola, Warren E. Zimmer and Alan R. Parrish

Department of Systems Biology and Translational Medicine, Texas A & M Health Science Center College of Medicine, College Station, Texas (HWS,ACD,ADA,WEZ,ARP), and Center for Bone, Joint and Spine Research, Department of Orthopaedics, Scott and White Hospital, Temple, Texas (HWS)

Correspondence to: H. Wayne Sampson, PhD, Department of Systems Biology and Translational Medicine, Texas A & M Health Science Center College of Medicine, 336 Reynolds Building, College Station, TX 77843-1114. E-mail: sampson{at}medicine.tamhsc.edu

Mouse tibial growth plates were examined for the presence of adhesion molecules using immunohistochemistry and RT-PCR. All of the components of the classical cadherin/catenin complex (cadherin, {alpha}-, ß-, and {gamma}-catenin), as well as a heavy presence of p120, were identified in the murine growth plate. All of the major cadherins (1-5, 11, 13, and 15) were, for the first time, identified and localized in the murine growth plate. We have demonstrated that most of the cadherins and catenins reside in the zone of hypertrophy. Only {alpha}-catenin and E-, P-, R-, and VE-cadherin were found in all regions of the growth plate. The results for T-cadherin were inconclusive. (J Histochem Cytochem 55:845–852, 2007)

Key Words: adhesion molecules • cadherins • catenins • bone • growth plate • hypertrophic zone


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