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Association of Cortactin and Fascin-1 Expression in Gastric Adenocarcinoma: Correlation With Clinicopathological Parameters

Wen-Chiuan Tsai, Jong-Shiaw Jin, Wei-Kuo Chang, De-Chuan Chan, Ming-Kung Yeh, Shiou-Chih Cherng, Li-Fan Lin, Lai-Fa Sheu and You-Chen Chao

Department of Pathology (W-CT,J-SJ,L-FS), Division of Hepatogastroenterology, Department of Internal Medicine (W-KC,Y-CC), Division of General Surgery, Department of Surgery (D-CC), Department of Clinical Pharmacology (M-KY), and Department of Nuclear Medicine (S-CC,L-FL), Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

Correspondence to: You-Chen Chao, MD, Division of Hepatogastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan. E-mail: ab95057{at}hotmail.com

Cortactin and fascin-1 are important factors in tumor progression. We tested the hypothesis that cortactin and fascin-1 expression correlates with clinicopathological parameters of gastric adenocarcinoma. Immunohistochemical analysis of cortactin and fascin-1 was done using tissue microarrays of 100 surgical specimens, including 20 well-differentiated, 20 moderately differentiated, and 60 poorly differentiated gastric adenocarcinomas. Among the 20 well-differentiated gastric adenocarcinomas, 15 cases (75%) showed negative or weak staining (1+); 5 cases (25%) had moderate (2+) or strong (3+) cortactin expression. Among the 60 poorly differentiated gastric adenocarcinomas, more than three-quarters of the cases (76.7%) had moderate or strong cortactin expression; 14 cases (23.3%) had weak staining. Of 20 well-differentiated gastric adenocarcinoma cases, 14 (70%) showed negative or weak staining of fascin-1, whereas nearly one-third (30%) had moderate or strong expression. Among the 60 poorly differentiated gastric adenocarcinomas, 32 (53.3%) exhibited moderate or strong fascin-1 expression; fewer than half of the cases showed negative or weak staining. Higher intensity of cortactin and fascin-1 staining correlated directly with more-advanced cancer stages (TNM) and inversely with survival rates. Our findings suggest the possibility that pharmacological inhibitors of cortactin and fascin-1 activity may slow down tumor progression and prolong survival time in patients with gastric adenocarcinomas. (J Histochem Cytochem 55:955–962, 2007)

Key Words: fascin-1 • cortactin • gastric adenocarcinoma • survival test • immunohistochemical staining

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