Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact

Originally published as JHC exPRESS on August 4, 2008.
doi:10.1369/jhc.2008.951632
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jhc.2008.951632v1
56/11/1013    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Szabó, A.
Right arrow Articles by Zádor, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Szabó, A.
Right arrow Articles by Zádor, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry
Volume 56 (11): 1013-1022, 2008
Copyright ©The Histochemical Society, Inc.

The Effect of Passive Movement on Denervated Soleus Highlights a Differential Nerve Control on SERCA and MyHC Isoforms

András Szabó, Frank Wuytack and Erno Zádor

Institute of Biochemistry, Faculty of General Medicine, University of Szeged, Szeged, Hungary (AS,EZ), and Laboratory of Ca2+-transport ATPases, Department of Molecular Cell Biology, K.U.Leuven, Leuven, Belgium (FW)

Correspondence to: Dr. Erno Zádor, Institute of Biochemistry, Faculty of General Medicine, University of Szeged, H-6720 Szeged, Hungary. E-mail: erno{at}biochem.szote.u-szeged.hu

The sarco-endoplasmic reticulum Ca2+ ATP-ase (SERCA) and myosin heavy chain (MyHC) levels were measured in hindlimb-denervated and selectively denervated rat soleus muscles. Selective denervation allowed passive movement of the soleus, whereas hindlimb denervation rendered it to passivity. To minimize chronic effects, we followed the changes only for 2 weeks. Selective denervation resulted in less muscle atrophy, a faster slow-to-fast transition of MyHC isoforms, and less coordinated expressions of the slow vs fast isoforms of MyHC and SERCA. Generally, expression of the slow-twitch type SERCA2a was found to be less dependent, whereas the slow-twitch type MyHC1 was the most dependent on innervation. Our study shows that passive movement is able to ameliorate denervation-induced atrophy of the soleus and that it also accentuates the dyscoordination in the expression of the corresponding slow and fast isoforms of MyHC and SERCA. (J Histochem Cytochem 56:1013–1022, 2008)

Key Words: SERCA • MyHC • selective denervation • passive movement


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
O. Agbulut, A. Vignaud, C. Hourde, E. Mouisel, F. Fougerousse, G. S. Butler-Browne, and A. Ferry
Slow myosin heavy chain expression in the absence of muscle activity
Am J Physiol Cell Physiol, January 1, 2009; 296(1): C205 - C214.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2008

 
Purchase HCS Short Course Manual on HCS site