Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
Originally published as JHC exPRESS on October 15, 2007.
doi:10.1369/jhc.7A7333.2007
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jhc.7A7333.2007v1
56/2/139    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Steigen, S. E.
Right arrow Articles by Lindal, S.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Steigen, S. E.
Right arrow Articles by Lindal, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Histochemistry and Cytochemistry
Volume 56 (2): 139-145, 2008
Copyright ©The Histochemical Society, Inc.

Clinicopathologic Factors and Nuclear Morphometry as Independent Prognosticators in KIT-positive Gastrointestinal Stromal Tumors

Sonja E. Steigen, Bjørn Straume, Dmitry Turbin, Andy K.W. Chan, Samuel Leung, Torsten O. Nielsen and Sigurd Lindal

Department of Pathology (SES,SLindal) and Institute of Community Medicine (BS), University of Tromsø, Tromsø, Norway, and Department of Pathology and Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, Canada (SES,DT,AKWC,SLeung,TON)

Correspondence to: Sonja E. Steigen, Department of Pathology, University of Tromsø, N-9037 Tromso, Norway. E-mail: Sonja.steigen{at}unn.no

Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms found in the gastrointestinal tract. The purpose of this study was to evaluate whether morphometric measurements could complement tumor size and mitotic activity in risk evaluation. Nuclear roundness and ellipse axis ratio were found to correlate with tumor size, mitotic activity, nuclear atypia, and hemorrhage. Morphometric variables in 422 GISTs were significant for overall survival in univariate analyses but did not retain independent significance in multivariate analyses incorporating mitotic count and tumor size. Traditional variables, together with sex, location of primary tumor, and nuclear atypia, seem to be the best parameters for prognostic evaluation. (J Histochem Cytochem 56:139–145, 2008)

Key Words: gastrointestinal stromal tumor • morphometry • roundness


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?





Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2008