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Originally published as JHC exPRESS on September 6, 2007.
doi:10.1369/jhc.7A7223.2007
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Journal of Histochemistry and Cytochemistry
Volume 56 (2): 89-95, 2008
Copyright ©The Histochemical Society, Inc.

Immunolocalization of IL-17A, IL-17B, and Their Receptors in Chondrocytes During Fracture Healing

Takeshi Kokubu, Dominik R. Haudenschild, Timothy A. Moseley, Larry Rose and A. Hari Reddi

Center for Tissue Regeneration and Repair, Department of Orthopedics, University of California, School of Medicine, Sacramento, California

Correspondence to: A. Hari Reddi, Center for Tissue Regeneration and Repair, Department of Orthopedics, University of California, School of Medicine, 4635 Second Avenue, Sacramento, CA 95817. E-mail: ahreddi{at}ucdavis.edu

Fracture healing in long bones is a sequential multistep cascade of hemostasis, transient inflammation, chemotaxis of progenitor cells, mitosis, differentiation of cartilage, and replacement with bone. This multistep cascade is orchestrated by cytokines and morphogens. Members of the interleukin (IL)-17 family, including IL-17B, have been identified in cartilage, but their expression during fracture healing is unknown. In this study, we determined the immunolocalization of cytokines IL-17A and IL-17B, along with the IL-17 receptor (IL-17R) and IL-17 receptor-like protein (IL-17RL), during the sequence of fracture repair in a standard model. The results were extended to developmental changes in the epiphyseal growth plate of long bones. Members of the IL-17 family were localized in chondrocytes in the fracture callus. Moreover, we found significant parallels to the localization of these cytokines and their receptors in chondrocytes during an endochondral differentiation program in the epiphyseal growth plate. (J Histochem Cytochem 56:89–95, 2008)

Key Words: interleukin-17B • interleukin-17 receptor-like protein • interleukin-17 receptor-like molecule • bone • chondrocyte • bone development • fracture healing


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