This Article Full Text Full Text (PDF) All Versions of this Article: jhc.2008.951566v1 57/3/187    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kaarteenaho-Wiik, R. Articles by Soini, Y. Search for Related Content PubMed PubMed Citation Articles by Kaarteenaho-Wiik, R. Articles by Soini, Y. Social Bookmarking                         What's this?

Claudin-1, -2, -3, -4, -5, and -7 in Usual Interstitial Pneumonia and Sarcoidosis

Riitta Kaarteenaho-Wiik and Ylermi Soini

Institute of Clinical Medicine, Department of Internal Medicine, Centre of Excellence in Research (RK-W), Institute of Diagnostics, Department of Pathology (RK-W,YS), and Clinical Research Center (RK-W), University of Oulu and Oulu University Hospital, Oulu, Finland, and Department of Clinical Pathology and Forensic Medicine, University of Kuopio, Kuopio, Finland (YS)

Correspondence to: Riitta Kaarteenaho-Wiik, MD, PhD, Institute of Clinical Medicine, Department of Internal Medicine, PO Box 5000, University of Oulu, Fi-90014 Oulu, Finland. E-mail: Riitta.Kaarteenaho-Wiik{at}oulu.fi

The aim of this study was to study the expression of various claudins in sarcoidosis, usual interstitial pneumonia (UIP), and normal human lung. The expression and cell-specific localization of claudin-1, -2, -3, -4, -5, and -7 was analyzed by IHC. Bronchiolar epithelial cells showed mostly strong expression for claudin-1, -2, -3, -4, and -7 and mainly weak expression for claudin-5 in UIP, sarcoidosis, and normal lung. Three claudins, claudin-3, -4, and -7, were expressed in normal alveolar epithelium, mainly in type II pneumocytes. Claudin-5 was expressed strongly in endothelium of normal lung, and its staining was extremely intense in endothelium of UIP. Moderate or strong expression for claudin-1, -2, -3, -4, and -7 was observed in metaplastic alveolar- and bronchiolar-type epithelium in UIP and also in metaplastic alveolar-type epithelium in sarcoidosis. Expression of claudin-5 was mainly weak in metaplastic alveolar- and bronchiolar-type epithelium in UIP. We conclude that claudin-1, -2, -3, -4, -5, and -7 are expressed in UIP and sarcoidosis, and furthermore, the most prominent enhancement of staining is localized in metaplastic alveolar- and bronchiolar-type epithelium in UIP compared with the healthy lung. (J Histochem Cytochem 57:187–195, 2009)

Key Words: epithelium • metaplasia • tight junction

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Koval Tight junctions, but not too tight: fine control of lung permeability by claudins Am J Physiol Lung Cell Mol Physiol, August 1, 2009; 297(2): L217 - L218. [Full Text] [PDF]

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact

The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2009