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JHC exPRESS: First Published December 20, 2005. doi:10.1369/jhc.5A6734.2005
Copyright © Histochemical Society, Inc.

A more recent version of this article appeared on March 1, 2006.
Originally published as JHC exPRESS on November 28, 2005.
doi:10.1369/jhc.5A6734.2005
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25-Hydroxyvitamin D3 1-{alpha}-Hydroxylase and Vitamin D Receptor Expression in Papillary Thyroid Carcinoma

K. Khadzkou 1, P. Buchwald 1, G. Westin 1, H. Dralle 1, G. Åkerström 1 and P. Hellman 1*

1 Department of Surgical Sciences, University Hospital, Uppsala, Sweden (KK,PB,GW,GA,PH); Department of Surgery, Vitebsk State Medical University, Vitebsk, Belarus (KK); and Department of Surgery, Martin-Luther University, Halle-Wittenberg, Germany (HD)

* To whom correspondence should be addressed. E-mail: per.hellman{at}surgsci.uu.se.

Submitted on May 17, 2005
Accepted on 8 November 2005


  Abstract
Background: Vitamin D receptor (VDR), and 25-hydroxyvitamin D3 1-{alpha}-hydroxylase expression have recently been shown to be upregulated in several tumors and thought to represent an important endogenous response to tumor progression. Little is known about the expression of these proteins in thyroid carcinoma, although previous reports have documented evidence of biological effect of vitamin D in thyroid cells. Design and Methods: Using paraffin-embedded and frozen sections of papillary thyroid carcinoma we utilized real-time quantitative RT-PCR and immunohistochemistry to characterize the expression of VDR and 1-{alpha}-hydroxylase in thyroid follicular cells, with special emphasis on papillary thyroid carcinoma (PTC). Results: VDR and 1-{alpha}-hydroxylase expression was increased in PTC compared with normal thyroid tissue and especially high in areas of lymphocyte infiltration. Conclusions: The expression of VDR and 1-{alpha}-hydroxylase in PTC may be compatible with an overall favorable prognosis for this tumor type, and may constitute important prerequisites for using vitamin D and/or vitamin D analogs in the treatment of PTC.

Key Words: thyroid carcinoma, vitamin D, 1-alpha-hydroxylase, immunohistochemistry, RT-PCR


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