Journal of Histochemistry and Cytochemistry Priciples for Free Access to Science
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
JHC exPRESS: First Published November 14, 2005. doi:10.1369/jhc.5A6803.2005
Copyright © Histochemical Society, Inc.

A more recent version of this article appeared on March 1, 2006.
This Article
Right arrow exPRESS PDF
Right arrow All Versions of this Article:
jhc.5A6803.2005v1
54/3/337    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Darling, M.R.
Right arrow Articles by Diamandis, E.P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Darling, M.R.
Right arrow Articles by Diamandis, E.P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Articles

Human Kallikrein 6 Expression in Salivary Gland Tumors

M.R. Darling 1*, L. Jackson-Boeters 1, T.D. Daley 1 and E.P. Diamandis 1

1 Department of Pathology, University of Western Ontario, London, Ontario, Canada (MRD,LJ-B,TDD), and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital (EPD) and Department of Laboratory Medicine and Pathobiology, (EPD),University of Toronto, Toronto, Ontario, Canada

* To whom correspondence should be addressed. E-mail: mark.darling{at}fmd.uwo.ca.

Submitted on August 3, 2005
Accepted on 27 October 2005


  Abstract
Human kallikrein 6 (hK6; also known as zyme/protease M/neurosin) is expressed in many normal glandular tissues. The aim of this study was to determine whether hK6 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), using an immunohistochemical method. Pleomorphic adenomas (PA), adenoid cystic carcinomas (ACC), polymorphous low grade adenocarcinomas (PLGA), acinic cell carcinomas (ACI), mucoepidermoid carcinomas (MEC) and adenocarcinomas NOS of both minor and major salivary glands were examined. Cells lining duct-like structures, and nonduct like cells were scored. Only in pleomorphic adenoma of minor salivary gland origin was overall staining higher in duct-like than in nonduct like cells; in all other tumors exhibiting both types of cells, hK6 staining was similar in both duct-like and nonduct like cells. Tumors which exhibited nonduct like cells only also exhibited cytoplasmic staining. The results of this study show that salivary gland tumors express hK6, apparently downregulated in comparison with normal salivary gland tissue, and that this expression is not specific for any of the tumors studied.

Key Words: kallikreins, human kallikrein 6, salivary gland tumors, prognostic markers, immunohistochemistry


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?





Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2005