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JHC exPRESS: First Published April 3, 2006. doi:10.1369/jhc.5A6869.2006
Copyright © Histochemical Society, Inc.

A more recent version of this article appeared on August 1, 2006.
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Articles

Caveolin-1 Expression Is Associated with Plaque Formation in Hypercholesterolemic Rabbits

Wei-Wen Lin 1, Yu-Chun Lin 1, Ti-Yu Chang 1, Shu-Huai Tsai 1, Hon-Chun Ho 1, Ying-Tsung Chen 1 and Vivian C. Yang 1*

1 Department of Life Science, Tunghai University, Taichung, Taiwan, Republic of China (W-WL,Y-CL,S-HT,H-CH,VCY), and Division of Cardiology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China (W-WL,T-YC,H-CH,Y-TC)

* To whom correspondence should be addressed. E-mail: vcyang{at}thu.edu.tw.

Submitted on November 11, 2005
Accepted on 11 March 2006


  Abstract
Caveolin-1, the major structural protein of caveolae, is present in several cell types that are known to play a role in the development of atherosclerosis. In this study, the distribution and expression of caveolin-1 in the arterial walls were studied in hypercholesterolemic rabbits. Immunohistochemical results indicated that the staining intensity of caveolin-1 reached a high level in the arterial intima at 5 weeks after high cholesterol diet treatment and decreased to a very low level at 8 weeks when athermatous plaques appeared. Western blot analysis showed that in rabbits fed a high cholesterol diet for 5 weeks, the expression of caveolin-1 reached to its highest level and then decreased from 8 to 12 weeks. The proliferative activity of smooth muscle cells (SMCs) decreased to the lowest level at 5 weeks and then increased at 8 and 12 weeks. The Nitric Oxide Synthase (NOS) activity gradually decreased in the animals fed a high cholesterol diet throughout the experiment. These studies demonstrate that the change in abundance of caveolin-1 is associated with SMCs proliferation in the formation of atheromatous plaque after hypercholesterolemia insult.

Key Words: caveolin-1, hypercholesterolemia, atheroma, smooth muscle cell proliferation, NOS activity


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