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JHC exPRESS: First Published July 11, 2006. doi:10.1369/jhc.5A6888.2006
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A more recent version of this article appeared on November 1, 2006.
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Distribution of Endothelin Receptor Subtypes ETA and ETB in the Rat Kidney

Martina Wendel 1*, Lilla Knels 1, Wolfgang Kummer 1 and Thea Koch 1

1 Department of Anesthesiology and Intensive Care Medicine, University Hospital Dresden, Dresden, Germany (MW,LK,TK), and Institute of Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany (WK)

* To whom correspondence should be addressed. E-mail: martina.wendel{at}tu-dresden.de.

Submitted on November 18, 2005
Accepted on 8 June 2006


  Abstract
The endothelin (ET)/ET-receptor system is markedly involved in the regulation of renal function under both physiologic and pathophysiologic conditions. ET-1 via its receptor subtypes ETA and ETB regulates both renal vascular tone and tubular function. The present study determined the detailed cellular localization of both ET-receptor subtypes, ETA and ETB, in the vascular and tubular system of the rat kidney.

Key Words: endothelin-1, ETA-receptor, ETB-receptor, rats, kidney, immunohistochemistry


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