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JHC exPRESS: First Published May 18, 2006. doi:10.1369/jhc.5A6912.2006
Copyright © Histochemical Society, Inc.

A more recent version of this article appeared on September 1, 2006.
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Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences

Sara Vander Borght 1*, Louis Libbrecht 1, Aezam Katoonizadeh 1, Jos van Pelt 1, David Cassiman 1, Frederik Nevens 1, Alfons Van Lommel 1, Bryon E. Petersen 1, Johan Fevery 1, Peter L. Jansen 1 and Tania A. Roskams 1

1 Laboratory of Morphology and Molecular Pathology (SVB,LL,AVL,TAR), Laboratory of Hepatology (AK,JvP,DC,FN,JF), University Hospitals Leuven, Leuven, Belgium; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Florida, USA (BEP); Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands (PLJ)

* To whom correspondence should be addressed. E-mail: Sara.vanderborght{at}uz.kuleuven.ac.be.

Submitted on December 23, 2005
Accepted on 29 April 2006


  Abstract
Breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette transport protein that is expressed in several organs, including the liver. Previous studies showed that ABC transport proteins play an important pathophysiological role in several liver diseases. However, the expression pattern and possible role of BCRP in human liver diseases and animal models have not yet been studied in detail.

Key Words: breast cancer resistance protein; immunohistochemistry; basolateral expression; hepatic progenitor cells; multidrug resistance phenotype; human and rat liver


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