Journal of Histochemistry and Cytochemistry
  Search:   
    >> Advanced Search

Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact

JHC exPRESS: First Published September 7, 2005. doi:10.1369/jhc.5B6752.2005
Journal of Histochemistry and Cytochemistry
Copyright © 2005 Ádori et al.

A more recent version of this article appeared on February 1, 2006.
This Article
Right arrow exPRESS PDF
Right arrow All Versions of this Article:
jhc.5B6752.2005v1
54/2/263    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ádori, C.
Right arrow Articles by Kovács, G. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ádori, C.
Right arrow Articles by Kovács, G. G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Brief Reports

Subcellular Distribution of Components of the Ubiquitin-Proteasome-System in Non-diseased Human and Rat Brain

Csaba Ádori 1, Péter Low 1, Moszkovkin Georgij 1, György Bagdy 1, Lajos László 1* and Gábor G. Kovács 1

1 Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University of Sciences, Budapest, Hungary (CÁ,PL,LL), and National Institute of Neurology and Psychiatry, Department of Neuropathology (MG,GGK) and Laboratory of Neurochemistry and Experimental Medicine (GB), Budapest, Hungary

* To whom correspondence should be addressed. E-mail: laszlo{at}cerberus.elte.hu.

Submitted on June 10, 2005
Accepted on 2 August 2005


  Abstract
Our aim was to investigate and compare the intracellular distribution of ubiquitin, 20S proteasome, and all six proteasomal regulatory ATPases in nondiseased human and rat brains. Ubiquitin and ATPases S4, S7 show dominant nuclear, whereas subunits S6a, S6b, S10b mainly cytoplasmic immunostaining in both species. However, S8 localization is inconsistent: prevailing nuclear in rat and cytoplasmic in human. In rat brain, small clastosome-like nuclear bodies demonstrate strong ubiquitin, 20S and S6a immunoreactivity both in neurons and glial cells. Prominent nuclear immunolocalization of members of the ubiquitin-proteasome-system provides morphological evidence for function of these proteins in transcription regulation and/or DNA repair.

Key Words: ubiquitin, proteasome, regulatory ATPase, clastosome, brain, immunohistochemistry


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
W. Shi, Z. Ma, H. Willers, K. Akhtar, S. P. Scott, J. Zhang, S. Powell, and J. Zhang
Disassembly of MDC1 Foci Is Controlled by Ubiquitin-Proteasome-dependent Degradation
J. Biol. Chem., November 14, 2008; 283(46): 31608 - 31616.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. von Mikecz
The nuclear ubiquitin-proteasome system
J. Cell Sci., May 15, 2006; 119(10): 1977 - 1984.
[Abstract] [Full Text] [PDF]



Guidelines | Subscriptions | About | exPRESS - Current - Archive | Business Information | Contact
The Journal of Histochemistry & Cytochemistry is owned, published, and licensed by The Histochemical Society © 2005

 
Purchase HCS Short Course Manual on HCS site