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JHC exPRESS: First Published August 21, 2006. doi:10.1369/jhc.6A6921.2006
Copyright © Histochemical Society, Inc.

A more recent version of this article appeared on December 1, 2006.
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Articles

CEACAM1 in Cervical Cancer and Precursor Lesions: Association With Human Papillomavirus Infection

Benibelks Albarran-Somoza 1, Ramon Franco-Topete 1, Vidal Delgado-Rizo 1, Felipe Cerda-Camacho 1, Lourdes Acosta-Jimenez 1, Miguel Lopez-Botet 1 and Adrian Daneri-Navarro 1*

1 Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México (BA-S,VD-R,LA-J,AD-N); Servicio de Patología, OPD Hospital Civil de Guadalajara, Guadalajara, México (RF-T,FC-C); and Molecular Immunopathology Unit DCEXS, Universitat Pompeu Fabra, Barcelona, Spain (ML-B)

* To whom correspondence should be addressed. E-mail: daneri{at}cucs.udg.mx.

Submitted on January 11, 2006
Accepted on 28 July 2006


  Abstract
CEACAM1 is an adhesion molecule expressed in a wide variety of tissues, including epithelial cells, leukocytes and tumors that may establish both homotypic and heterotypic interactions. The aim of this work was to study the protein expression pattern of CEACAM1 in cervical cancer and precursor lesions, in the context of HPV infection. We used immunohistochemistry to analyze CEACAM1 expression in fixed paraffin-embedded cervical tissues from 15 healthy women, 15 patients with low-grade SIL, 15 patients with high-grade SIL and 15 patients with squamous carcinomas. HPV types were identified by PCR. CEACAM1 was either undetectable (13 out of 15) or low (2 out of 15) in normal cervical tissues. By contrast, CEACAM1 expression was increased in high grade SIL (10 samples staining intermediate/high and 4 samples staining low), as compared with low-grade SIL with undetectable (n=3) or low (n=12) expression. CEACAM1 expression was undetectable or low in cervical carcinoma. Our results suggest that CEACAM1 may be an interesting progression marker in SIL and cervical cancer, in particular due to reported immunoregulatory properties.

Key Words: CEACAM1, cell adhesion, squamous intraepithelial lesions, cervical cancer, human papillomavirus (HPV)


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