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JHC exPRESS: First Published July 11, 2006. doi:10.1369/jhc.6A6923.2006
Copyright © Histochemical Society, Inc.

A more recent version of this article appeared on December 1, 2006.
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SOX13 Exhibits a Distinct Spatial and Temporal Expression Pattern During Chondrogenesis, Neurogenesis, and Limb Development

Yi Wang 1, Sika Ristevski 1 and Vincent R. Harley 1*

1 Human Molecular Genetics Laboratory, Prince Henry’s Institute of Medical Research, Victoria, Australia (YW,VRH); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia (YW); and Monash Institute of Medical Research, Monash University, Victoria, Australia (SR)

* To whom correspondence should be addressed. E-mail: Vincent.Harley{at}phimr.monash.edu.au.

Submitted on January 11, 2006
Accepted on 23 June 2006


  Abstract
SOX13 is a member of the SOX family of transcription factors. SOX proteins play essential roles in development and some are associated with human genetic diseases. SOX13 maps to a multi-disease locus on chromosome 1q31-32, yet its function is not known. Here we describe the temporal and spatial expression of SOX13 protein during mouse organogenesis. SOX13 is expressed in the three embryonic cell lineages suggesting that it may direct various developmental processes. SOX13 is expressed in the developing central nervous system including the neural tube and the developing brain. Expression is also detected in the condensing mesenchyme and cartilage progenitor cells during endochondral bone formation in the limb as well as the somite sclerotome and its derivatives. SOX13 is also detected in the developing kidney, pancreas, and liver as well as in the visceral mesoderm of the extra-embryonic yolk sac and spongiotrophoblast layer of the placenta.

Key Words: SOX13, mouse embryonic development, expression pattern, neural tube, endochondral bone, sclerotome, visceral mesoderm, spongiotrophoblast


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